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ALL MEDICAL CODES IN CATEGORY Certain disorders involving the immune mechanism (D80-D89)

2025 ICD-10-CM code D84.1

Defects in the complement system, such as C1 esterase inhibitor [C1-INH] deficiency.

2025 ICD-10-CM code D86.0

Sarcoidosis of lung.

2025 ICD-10-CM code D89.81

Graft-versus-host disease. Code first the underlying cause, such as complications of transplanted organs and tissues (T86.-) or complications of blood transfusion (T80.89).

2025 ICD-10-CM code D89.811

Chronic graft-versus-host disease. This condition is an immune disorder characterized by a recipient’s abnormal response to a donor organ, bone marrow, or stem cells that persists over time or occurs post-acute GVHD.

2025 ICD-10-CM code D89.833

Cytokine release syndrome, grade 3. This is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction.

2025 ICD-10-CM code D86.89

Sarcoidosis of other sites.This includes hepatic granuloma and uveoparotid fever [Heerfordt].

2025 ICD-10-CM code D89.3

Immune reconstitution syndrome.A condition where the immune system, after being suppressed (e.g., by HIV), rebounds excessively when treatment begins, causing an inflammatory response against infections or the body's own tissues.

2025 ICD-10-CM code D80.4

Selective deficiency of immunoglobulin M (IgM).

2025 ICD-10-CM code D86.83

Sarcoid iridocyclitis. This is the most common ocular complication of sarcoidosis, involving inflammatory granulomatous lesions affecting the iris and ciliary body of the eye.

2025 ICD-10-CM code D86.8

Sarcoidosis of other sites. This code encompasses sarcoidosis affecting areas not specifically classified elsewhere.

2025 ICD-10-CM code D81.89

This code represents other combined immunodeficiencies, a group of inherited disorders causing recurrent infections and other immune-related problems, not classified elsewhere.

2025 ICD-10-CM code D80

Immunodeficiency with predominantly antibody defects (PADs). This encompasses a range of disorders characterized by increased susceptibility to infections and autoimmune diseases due to impaired antibody production or function.

2025 ICD-10-CM code D89.82

Autoimmune lymphoproliferative syndrome (ALPS)

2025 ICD-10-CM code D81.5

Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disorder affecting the immune system.

2025 ICD-10-CM code D81.32

Adenosine deaminase 2 deficiency.

2025 ICD-10-CM code D80.8

Other immunodeficiencies with predominantly antibody defects. This encompasses various conditions not specifically classified elsewhere, characterized by impaired antibody production or function, leading to increased susceptibility to infections.

2025 ICD-10-CM code D86.2

Sarcoidosis of lung with sarcoidosis of lymph nodes.

2025 ICD-10-CM code D80.0

Hereditary hypogammaglobulinemia is a condition characterized by low levels of immunoglobulins in the blood due to a genetic defect.

2025 ICD-10-CM code D81.4

Nezelof syndrome is a rare, inherited immunodeficiency disorder characterized by underdevelopment of the thymus gland, leading to T-cell deficiency but normal immunoglobulin levels.

2025 ICD-10-CM code D81.818

Other biotin-dependent carboxylase deficiency. This includes holocarboxylase synthetase deficiency and other multiple carboxylase deficiencies.

2025 ICD-10-CM code D83.2

Common variable immunodeficiency (CVID) with autoantibodies to B- or T-cells.

2025 ICD-10-CM code D81.2

Severe combined immunodeficiency (SCID) with low or normal B-cell numbers is a type of SCID where T cells are absent, and B and/or NK cell counts can be low, none, high, or normal.B cells, even if present, are non-functional due to the absence of T cells.

2025 ICD-10-CM code D83.1

Common variable immunodeficiency (CVID) with predominant immunoregulatory T-cell disorders.

2025 ICD-10-CM code D84.9

Unspecified immunodeficiency. This code is used when the provider does not document the specific type of immunodeficiency.

2025 ICD-10-CM code D84.0

Lymphocyte function antigen-1 (LFA-1) defect, also known as CD11a/CD18 defect, is a rare genetic immunodeficiency that affects leukocyte function.

2025 ICD-10-CM code D83

Common variable immunodeficiency (CVID) is a disorder characterized by low levels of serum immunoglobulins, resulting in increased susceptibility to infections.

2025 ICD-10-CM code D81.7

Major histocompatibility complex class II deficiency, an inherited immunodeficiency where MHC class II proteins are decreased or absent on blood cells due to genetic mutation.

2025 ICD-10-CM code D84

Other immunodeficiencies.

2025 ICD-10-CM code D86.1

Sarcoidosis of the lymph nodes.

2025 ICD-10-CM code D81.6

Major histocompatibility complex class I deficiency, also known as bare lymphocyte syndrome.

2025 ICD-10-CM code D86.81

Sarcoid meningitis is the inflammation of the membranes surrounding the brain and spinal cord, caused by sarcoidosis.

2025 ICD-10-CM code D89.89

Other specified disorders involving the immune mechanism, not elsewhere classified.

2025 ICD-10-CM code D89.810

Acute graft-versus-host disease.

2025 ICD-10-CM code D83.8

Other common variable immunodeficiencies (CVIDs) involve the body's immune system being unable to fight infection due to B lymphocytes or plasma cells not producing antibodies. This leads to low immunoglobulin levels and frequent bacterial infections.

2025 ICD-10-CM code D86

Sarcoidosis is a condition characterized by the formation of granulomas (small clumps of inflammatory cells) in one or more organs of the body.

2025 ICD-10-CM code D89.44

Hereditary alpha tryptasemia.This condition is characterized by elevated levels of alpha tryptase, a protein released by mast cells.

2025 ICD-10-CM code D80.7

Transient hypogammaglobulinemia of infancy is a condition characterized by low levels of IgG antibodies around 6 months of age, typically resolving by 24 months.

2025 ICD-10-CM code D82.3

Immunodeficiency following hereditary defective response to Epstein-Barr virus (X-linked lymphoproliferative disease).

2025 ICD-10-CM code D86.85

Sarcoid myocarditis is an inflammatory condition affecting the heart muscle, leading to non-necrotizing granuloma-like lesions and post-inflammatory scar tissue.

2025 ICD-10-CM code D86.3

Sarcoidosis of the skin.

2025 ICD-10-CM code D89.0

Polyclonal hypergammaglobulinemia. This condition involves elevated levels of IgG, IgA, and IgM resulting from various underlying diseases.

2025 ICD-10-CM code D80.5

Immunodeficiency with increased immunoglobulin M [IgM]. This is an inherited immunological disorder characterized by an increased level of IgM antibodies due to the inability to produce other antibodies (IgG, IgA, and IgE).

2025 ICD-10-CM code D89.8

Other specified disorders involving the immune mechanism, not elsewhere classified.

2025 ICD-10-CM code D81.3

Adenosine deaminase (ADA) deficiency, a genetic disorder causing severe combined immunodeficiency (SCID), impairs lymphocyte development and function, leading to increased susceptibility to infections.

2025 ICD-10-CM code D82.0

Wiskott-Aldrich syndrome, a rare X-linked recessive genetic disorder characterized by immunodeficiency, eczema, and thrombocytopenia (low platelet count).

2025 ICD-10-CM code D89.4

Mast cell activation syndrome and related disorders. This condition involves the inappropriate and excessive release of chemical mediators by mast cells, leading to a range of chronic symptoms.

2025 ICD-10-CM code D81.1

Severe combined immunodeficiency (SCID) with low T- and B-cell numbers.

2025 ICD-10-CM code D80.6

Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia. This condition involves an inadequate response to some antigens despite near-normal or increased immunoglobulin levels.

2025 ICD-10-CM code D81.9

Combined immunodeficiency, unspecified. This condition involves an inherited disorder leading to recurrent, severe, and/or opportunistic infections, inflammatory diseases, autoimmune conditions, excessive lymphocytes, and increased malignancy risk.The specific type of CID is not specified.

2025 ICD-10-CM code D89.42

Idiopathic mast cell activation syndrome (MCAS) is characterized by the inappropriate activation of mast cells, leading to an excessive release of histamine and heparin, causing an abnormal response to allergens without a known cause.