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ALL MEDICAL CODES IN CATEGORY Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

2025 CPT code 81465

Whole mitochondrial genome large deletion analysis panel (e.g., Kearns-Sayre syndrome, chronic progressive external ophthalmoplegia), including heteroplasmy detection, if performed.

2025 CPT code 81426

Genome (e.g., unexplained constitutional or heritable disorder or syndrome); sequence analysis, each comparator genome (eg, parents, siblings) (List separately in addition to code for primary procedure)

2025 CPT code 81419

Epilepsy genomic sequence analysis panel, includes analyses for at least 24 specified genes.

2025 CPT code 81439

Genomic sequence analysis panel for hereditary cardiomyopathy, including sequencing of at least 5 cardiomyopathy-related genes (e.g., DSG2, MYBPC3, MYH7, PKP2, TTN).

2025 CPT code 81430

Genomic sequence analysis panel for hearing loss, including sequencing of at least 60 genes.

2025 CPT code 81442

Noonan spectrum disorders (e.g., Noonan syndrome, cardio-facio-cutaneous syndrome, Costello syndrome, LEOPARD syndrome, Noonan-like syndrome), genomic sequence analysis panel, must include sequencing of at least 12 genes, including BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, RIT1, SHOC2, and SOS1.

2025 CPT code 81416

Exome sequence analysis; each comparator exome (e.g., parents, siblings).

2025 CPT code 81422

Genomic sequence analysis of circulating cell-free fetal DNA in maternal blood for chromosomal microdeletions (e.g., DiGeorge syndrome, Cri-du-chat syndrome).

2025 CPT code 81451

Genomic sequence analysis panel evaluating RNA alterations in 5-50 genes related to hematolymphoid cancers or disorders.

2025 CPT code 81457

Genomic sequence analysis panel for solid organ neoplasm; DNA analysis for sequence variants and microsatellite instability (MSI).

2025 CPT code 81434

Genomic sequence analysis panel for hereditary retinal disorders; includes sequencing of at least 15 genes.

2025 CPT code 81418

This code represents a genomic sequence analysis panel for drug metabolism (pharmacogenomics) that includes at least six genes, notably CYP2C19 and CYP2D6, with CYP2D6 duplication/deletion analysis.

2025 CPT code 81449

Genomic sequence analysis panel for RNA alterations in 5-50 genes impacting solid organ cancers.

2025 CPT code 81410

Genomic sequence analysis panel for aortic dysfunction or dilation, including at least 9 genes (FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, MYLK).

2025 CPT code 81464

Genomic sequence analysis panel evaluating cell-free nucleic acid (e.g., plasma) for sequence variants, copy number variants, rearrangements, microsatellite instability (MSI), and tumor mutation burden (TMB) in solid organ neoplasms.

2025 CPT code 81471

Analyzes a patient specimen for duplication and deletion mutations in at least 60 genes, including 15 genes related to X-linked intellectual disability (XLID).

2025 CPT code 81411

Duplication/deletion analysis panel for genes related to aortic dysfunction or dilation (e.g., Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome type IV, arterial tortuosity syndrome); must include TGFBR1, TGFBR2, MYH11, and COL3A1.

2025 CPT code 81462

Genomic sequence analysis panel for solid organ neoplasms using cell-free nucleic acid (e.g., plasma) to detect sequence variants, copy number variants, and rearrangements.

2025 CPT code 81413

Genomic sequence analysis panel for cardiac ion channelopathies; includes sequencing of at least 10 genes.

2025 CPT code 81448

Genomic sequence analysis panel for hereditary peripheral neuropathies; includes at least 5 related genes.

2025 CPT code 81438

Duplication/deletion analysis panel for hereditary neuroendocrine tumor disorders. Must include analyses for SDHB, SDHC, SDHD, and VHL.

2025 CPT code 81425

Genome (e.g., unexplained constitutional or heritable disorder or syndrome); sequence analysis

2025 CPT code 81433

Duplication/deletion analysis panel for hereditary breast cancer-related disorders, including analyses for BRCA1, BRCA2, MLH1, MSH2, and STK11.

2025 CPT code 81414

Duplication/deletion analysis of at least two genes, including KCNH2 and KCNQ1, for cardiac ion channelopathies (e.g., Brugada syndrome, long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia).

2025 CPT code 81441

Inherited bone marrow failure syndromes (IBMFS) sequence analysis panel, must include sequencing of at least 30 genes, including BRCA2, BRIP1, DKC1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, GATA1, GATA2, MPL, NHP2, NOP10, PALB2, RAD51C, RPL11, RPL35A, RPL5, RPS10, RPS19, RPS24, RPS26, RPS7, SBDS, TERT, and TINF2

2025 CPT code 81455

Genomic sequence analysis panel for solid organ or hematolymphoid neoplasms, evaluating 51 or more genes for DNA and possibly RNA alterations.

2025 CPT code 81440

Genomic sequence analysis panel for nuclear encoded mitochondrial genes (neurologic or myopathic phenotypes), must include analysis of at least 100 genes including BCS1L, C10orf2, COQ2, COX10, DGUOK, MPV17, OPA1, PDSS2, POLG, POLG2, RRM2B, SCO1, SCO2, SLC25A4, SUCLA2, SUCLG1, TAZ, TK2, and TYMP.

2025 CPT code 81458

Genomic sequence analysis panel for solid organ neoplasm evaluating DNA sequence variants, copy number variants, and microsatellite instability (MSI).

2025 CPT code 81412

Genomic sequence analysis panel for Ashkenazi Jewish associated disorders; must include sequencing of at least 9 genes (ASPA, BLM, CFTR, FANCC, GBA, HEXA, IKBKAP, MCOLN1, and SMPD1).

2025 CPT code 81436

Analyzes a patient specimen for duplication and deletion mutations of at least five genes related to hereditary colon cancer syndromes.

2025 CPT code 81460

Genomic sequencing of the entire mitochondrial genome, including heteroplasmy detection.

2025 CPT code 81431

Hearing loss (e.g., nonsyndromic hearing loss, Usher syndrome, Pendred syndrome); duplication/deletion analysis panel, including copy number analyses for STRC and DFNB1 and deletions in GJB2 and GJB6 genes.

2025 CPT code 81435

Genomic sequencing analysis panel for hereditary colon cancer; at least 10 genes sequenced.

2025 CPT code 81420

Genomic sequence analysis panel for fetal chromosomal aneuploidy using circulating cell-free fetal DNA in maternal blood; includes chromosomes 13, 18, and 21.

2025 CPT code 81432

Genomic sequence analysis panel for hereditary breast cancer-related disorders; must include at least 10 genes, including BRCA1, BRCA2, CDH1, MLH1, MSH2, MSH6, PALB2, PTEN, STK11, and TP53.

2025 CPT code 81417

Re-evaluation of a previously obtained exome sequence; for example, due to updated knowledge or an unrelated condition/syndrome.

2025 CPT code 81443

Genomic sequence analysis panel for severe inherited conditions; must include at least 15 genes.

2025 CPT code 81437

Genomic sequence analysis panel for hereditary neuroendocrine tumor disorders; must include at least six genes (e.g., MAX, SDHB, SDHC, SDHD, TMEM127, and VHL).

2025 CPT code 81445

Genomic sequence analysis panel for solid organ neoplasm; 5-50 genes; DNA or combined DNA/RNA analysis.

2025 CPT code 81470

Genomic sequence analysis panel for X-linked intellectual disability (XLID), including at least 60 genes.

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