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ALL MEDICAL CODES IN CATEGORY Molecular Pathology

2025 CPT code 81343

PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 0005U

Oncology (prostate) gene expression profile by real-time RT-PCR of 3 genes (ERG, PCA3, and SPDEF), urine, algorithm reported as risk score.

2025 CPT code 81433

Duplication/deletion analysis panel for hereditary breast cancer-related disorders, including analyses for BRCA1, BRCA2, MLH1, MSH2, and STK11.

2025 CPT code 81283

IFNL3 (interferon, lambda 3) (eg, drug response), gene analysis, rs12979860 variant

2025 CPT code 81322

PTEN (phosphatase and tensin homolog) (eg, Cowden syndrome, PTEN hamartoma tumor syndrome) gene analysis; known familial variant

2025 CPT code 0238U

Oncology (Lynch syndrome), genomic DNA sequence analysis of MLH1, MSH2, MSH6, PMS2, and EPCAM, including small sequence changes in exonic and intronic regions, deletions, duplications, mobile element insertions, and variants in non-uniquely mappable regions.

2025 CPT code 0239U

Targeted genomic sequence analysis panel for solid organ neoplasm using cell-free DNA, analyzing 311 or more genes for sequence variants including substitutions, insertions, deletions, select rearrangements, and copy number variations.

2025 CPT code 0114U

VIM and CCNA1 methylation analysis of esophageal cells to assess the likelihood of Barrett's esophagus.

2025 CPT code 0307U

Oncology (minimal residual disease [MRD]), next-generation targeted sequencing analysis of a patient-specific panel, cell-free DNA, subsequent assessment with comparison to previously analyzed patient specimens to evaluate for MRD. Do not report 0307U in conjunction with 0306U.

2025 CPT code +0136U

Targeted mRNA sequence analysis of the ATM gene; reported separately in addition to the code for the primary procedure.

2025 CPT code 81432

Genomic sequence analysis panel for hereditary breast cancer-related disorders; must include at least 10 genes, including BRCA1, BRCA2, CDH1, MLH1, MSH2, MSH6, PALB2, PTEN, STK11, and TP53.

2025 CPT code 81202

Analysis of known familial variants in the adenomatous polyposis coli (APC) gene.

2025 CPT code 81449

Genomic sequence analysis panel for RNA alterations in 5-50 genes impacting solid organ cancers.

2025 CPT code 81258

HBA1/HBA2 (alpha globin 1 and alpha globin 2) gene analysis for known familial variants.

2025 CPT code 81360

ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine-rich 2) (eg, myelodysplastic syndrome, acute myeloid leukemia) gene analysis, common variant(s) (eg, E65fs, E122fs, R448fs).

2025 CPT code 0133U

Hereditary prostate cancer-related disorders, targeted mRNA sequence analysis panel (11 genes). This test is performed in addition to the primary procedure.

2025 CPT code 0049U

NPM1 (nucleophosmin) gene analysis, quantitative.

2025 CPT code 0060U

Twin zygosity, genomic-targeted sequence analysis of chromosome 2, using circulating cell-free fetal DNA in maternal blood.

2025 CPT code 0368U

Oncology (colorectal cancer), evaluation for mutations of APC, BRAF, CTNNB1, KRAS, NRAS, PIK3CA, SMAD4, and TP53, and methylation markers (MYO1G, KCNQ5, C9ORF50, FLI1, CLIP4, ZNF132, and TWIST1), multiplex quantitative polymerase chain reaction (qPCR), circulating cell-free DNA (cfDNA), plasma, report of risk score for advanced adenoma or colorectal cancer.

2025 CPT code 0137U

PALB2 (partner and localizer of BRCA2) mRNA sequence analysis; add-on code.

2025 CPT code 0023U

This CPT code, 0023U, represents the LeukoStrat® CDx FLT3 Mutation Assay, a molecular pathology test identifying FLT3 gene mutations in acute myeloid leukemia (AML) patients to guide treatment decisions.

2025 CPT code 81217

BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; known familial variant

2025 CPT code 0101U

Hereditary colon cancer disorders (e.g., Lynch syndrome, PTEN hamartoma syndrome, Cowden syndrome, familial adenomatosis polyposis), genomic sequence analysis panel utilizing a combination of NGS, Sanger, MLPA, and array CGH, with mRNA analytics to resolve variants of unknown significance when indicated (15 genes [sequencing and deletion/duplication], EPCAM and GREM1 [deletion/duplication only]).

2025 CPT code 0036U

Exome (i.e., somatic mutations), paired formalin-fixed paraffin-embedded tumor tissue and normal specimen, sequence analyses.

2025 CPT code 0242U

Targeted genomic sequence analysis panel, solid organ neoplasm, cell-free circulating DNA analysis of 55-74 genes.

2025 CPT code 0313U

Oncology (pancreas), DNA and mRNA next-generation sequencing analysis of 74 genes and analysis of CEA (CEACAM5) gene expression, pancreatic cyst fluid, algorithm reported as a categorical result (i.e., negative, low probability of neoplasia or positive, high probability of neoplasia).

2025 CPT code 81541

mRNA gene expression profiling by real-time RT-PCR of 46 genes (31 content and 15 housekeeping) from formalin-fixed paraffin-embedded prostate tissue; algorithm reported as a disease-specific mortality risk score.

2025 CPT code 81435

Genomic sequencing analysis panel for hereditary colon cancer; at least 10 genes sequenced.

2025 CPT code 81457

Genomic sequence analysis panel for solid organ neoplasm; DNA analysis for sequence variants and microsatellite instability (MSI).

2025 CPT code 0161U

mRNA sequence analysis of the PMS2 gene; used in conjunction with a primary procedure code (81317) for hereditary non-polyposis colorectal cancer (Lynch syndrome) diagnosis.