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ALL MEDICAL CODES IN CATEGORY Molecular Pathology Procedures

2025 CPT code 81273

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (eg, mastocytosis), gene analysis, D816 variant(s).

2025 CPT code 81258

HBA1/HBA2 (alpha globin 1 and alpha globin 2) gene analysis for known familial variants.

2025 CPT code 81230

Analysis of the CYP3A4 gene for common variants (e.g., *2, *22) to assess drug metabolism.

2025 CPT code 81247

G6PD (glucose-6-phosphate dehydrogenase) (eg, hemolytic anemia, jaundice), gene analysis; common variant(s) (eg, A, A-)

2025 CPT code 81316

PML/RARalpha,(t(15;17)), (promyelocytic leukemia/retinoic acid receptor alpha) (eg, promyelocytic leukemia) translocation analysis; single breakpoint (eg, intron 3, intron 6 or exon 6), qualitative or quantitative. (For intron 3 and intron 6 [including exon 6 if performed] analysis, use 81315). (If both intron 6 and exon 6 are analyzed, without intron 3, use one unit of 81316)

2025 CPT code 81275

KRAS (Kirsten rat sarcoma viral oncogene homolog) (eg, carcinoma) gene analysis; variants in exon 2 (eg, codons 12 and 13)

2025 CPT code 81380

HLA Class I typing, high resolution (ie, alleles or allele groups); one locus (eg, HLA-A, -B, or -C), each.

2025 CPT code 81402

Molecular pathology procedure, level 3.This includes analysis of >10 single nucleotide polymorphisms (SNPs), 2-10 methylated variants, 2-10 somatic variants, immunoglobulin and T-cell receptor gene rearrangements, duplication/deletion variants of one exon, loss of heterozygosity (LOH), and uniparental disomy (UPD).

2025 CPT code 81278

IGH@/BCL2 (t(14;18)) (eg, follicular lymphoma) translocation analysis, major breakpoint region (MBR) and minor cluster region (mcr) breakpoints, qualitative or quantitative.

2025 CPT code 81107

Human Platelet Antigen 3 (HPA-3) genotyping, ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex], antigen CD41 [GPIIb]) (e.g., neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), gene analysis, common variant, HPA-3a/b (I843S)

2025 CPT code 81201

APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene analysis; full gene sequence

2025 CPT code 81205

Branched-chain keto acid dehydrogenase E1, beta polypeptide (BCKDHB) (e.g., maple syrup urine disease) gene analysis, common variants (e.g., R183P, G278S, E422X).

2025 CPT code 81219

CALR (calreticulin) (eg, myeloproliferative disorders), gene analysis, common variants in exon 9

2025 CPT code 81218

CEBPA (CCAAT/enhancer binding protein [C/EBP], alpha) (eg, acute myeloid leukemia), gene analysis, full gene sequence.

2025 CPT code 81323

PTEN (phosphatase and tensin homolog) (eg, Cowden syndrome, PTEN hamartoma tumor syndrome) gene analysis; duplication/deletion variant

2025 CPT code 81232

Analysis of common variants in the dihydropyrimidine dehydrogenase (DPYD) gene (e.g., *2A, *4, *5, *6) to assess drug metabolism, primarily for 5-fluorouracil (5-FU) and capecitabine.

2025 CPT code 81193

Analysis of NTRK3 (neurotrophic receptor tyrosine kinase 3) gene translocations, often associated with certain solid tumors.

2025 CPT code 81246

Analysis of FLT3 gene for tyrosine kinase domain (TKD) variants.

2025 CPT code 81194

Analysis of NTRK1, NTRK2, and NTRK3 gene translocations.

2025 CPT code 81351

Analysis of the entire TP53 gene sequence; full gene sequencing.

2025 CPT code 81338

Analysis of common MPL gene variants (e.g., W515A, W515K, W515L, W515R) associated with myeloproliferative neoplasms.

2025 CPT code 81328

Analysis of the SLCO1B1 gene for common variants (e.g., *5).

2025 CPT code 81326

Analysis of the PMP22 gene for known familial variants associated with conditions like Charcot-Marie-Tooth disease and hereditary neuropathy with liability to pressure palsies.

2025 CPT code 81370

HLA Class I and II typing, low resolution, molecular techniques.

2025 CPT code 81109

Analysis of common Human Platelet Antigen 5 (HPA-5) gene variants (e.g., HPA-5a/b [K505E]) using a patient specimen (e.g., blood).

2025 CPT code 81216

Analysis of the complete BRCA2 gene sequence.

2025 CPT code 81307

Analysis of the entire PALB2 gene sequence; detects variants associated with breast and pancreatic cancer risk.

2025 CPT code 81252

Analysis of the complete GJB2 gene sequence, encompassing all exons and introns, to identify variations associated with hearing loss.

2025 CPT code 81378

High-resolution HLA typing for Class I (HLA-A, -B, -C) and Class II (HLA-DRB1) using molecular techniques.

2025 CPT code 81400

Molecular pathology procedure, Level 1;identifies single germline variants using techniques like restriction enzyme digestion or melt curve analysis.

2025 CPT code 81222

Analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene for duplication/deletion variants.

2025 CPT code 81189

Analysis of the full cystatin B gene (CSTB) sequence.

2025 CPT code 81215

Analysis of known familial variants in the BRCA1 gene.

2025 CPT code 81318

Analysis of the PMS2 gene for known familial variants.

2025 CPT code 81319

Analysis of PMS2 gene for duplication/deletion variants.

2025 CPT code 81121

IDH2 (isocitrate dehydrogenase 2 [NADP+], mitochondrial) (eg, glioma), common variants (eg, R140W, R172M).

2025 CPT code 81377

HLA Class II typing, low resolution (e.g., antigen equivalents); one antigen equivalent, each.

2025 CPT code 81238

F9 (coagulation factor IX) (eg, hemophilia B), full gene sequence

2025 CPT code 81372

HLA Class I typing, low resolution (e.g., antigen equivalents); complete (i.e., HLA-A, -B, and -C)

2025 CPT code 81379

HLA Class I typing, high resolution (ie, alleles or allele groups); complete (ie, HLA-A, -B, and -C)

2025 CPT code 81315

PML/RARalpha,(t(15;17)), (promyelocytic leukemia/retinoic acid receptor alpha) (eg, promyelocytic leukemia) translocation analysis; common breakpoints (eg, intron 3 and intron 6), qualitative or quantitative

2025 CPT code 81167

BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; full duplication/deletion analysis (ie, detection of large gene rearrangements).

2025 CPT code 81171

AFF2 (ALF transcription elongation factor 2 [FMR2]) (eg, fragile X intellectual disability 2 [FRAXE]) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81188

CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81172

AFF2 (ALF transcription elongation factor 2 [FMR2]) (eg, fragile X intellectual disability 2 [FRAXE]) gene analysis; characterization of alleles (eg, expanded size and methylation status).

2025 CPT code 81186

CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene analysis; known familial variant

2025 CPT code 81187

CNBP (CCHC-type zinc finger nucleic acid binding protein) (eg, myotonic dystrophy type 2) gene analysis, evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81264

Immunoglobulin kappa light chain locus (IGK) gene rearrangement analysis to detect abnormal clonal populations (e.g., in leukemia and lymphoma, B-cell).

2025 CPT code 81303

MECP2 (methyl CpG binding protein 2) (eg, Rett syndrome) gene analysis; known familial variant

2025 CPT code 81267

Chimerism (engraftment) analysis, post transplantation specimen (e.g., hematopoietic stem cell), includes comparison to previously performed baseline analyses; without cell selection.