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ALL MEDICAL CODES IN CATEGORY Molecular Pathology Procedures

2025 CPT code 81273

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (eg, mastocytosis), gene analysis, D816 variant(s).

2025 CPT code 81355

Analysis of VKORC1 gene for common variants related to warfarin metabolism.

2025 CPT code 81210

BRAF (B-Raf proto-oncogene, serine/threonine kinase) gene analysis for V600 variant(s).

2025 CPT code 81383

HLA Class II typing, high resolution (ie, alleles or allele groups); one allele or allele group (eg, HLA-DQB1*06:02P), each

2025 CPT code 81121

IDH2 (isocitrate dehydrogenase 2 [NADP+], mitochondrial) (eg, glioma), common variants (eg, R140W, R172M).

2025 CPT code 81377

HLA Class II typing, low resolution (e.g., antigen equivalents); one antigen equivalent, each.

2025 CPT code 81272

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (e.g., gastrointestinal stromal tumor [GIST], acute myeloid leukemia, melanoma), gene analysis, targeted sequence analysis (e.g., exons 8, 11, 13, 17, 18).

2025 CPT code 81238

F9 (coagulation factor IX) (eg, hemophilia B), full gene sequence

2025 CPT code 81258

HBA1/HBA2 (alpha globin 1 and alpha globin 2) gene analysis for known familial variants.

2025 CPT code 81230

Analysis of the CYP3A4 gene for common variants (e.g., *2, *22) to assess drug metabolism.

2025 CPT code 81247

G6PD (glucose-6-phosphate dehydrogenase) (eg, hemolytic anemia, jaundice), gene analysis; common variant(s) (eg, A, A-)

2025 CPT code 81329

SMN1 (survival of motor neuron 1, telomeric) (e.g., spinal muscular atrophy) gene analysis; dosage/deletion analysis (e.g., carrier testing), includes SMN2 (survival of motor neuron 2, centromeric) analysis, if performed.

2025 CPT code 81357

U2AF1 (U2 small nuclear RNA auxiliary factor 1) gene analysis, common variants (e.g., S34F, S34Y, Q157R, Q157P).

2025 CPT code 81360

ZRSR2 (zinc finger CCCH-type, RNA binding motif and serine/arginine-rich 2) (eg, myelodysplastic syndrome, acute myeloid leukemia) gene analysis, common variant(s) (eg, E65fs, E122fs, R448fs).

2025 CPT code 81372

HLA Class I typing, low resolution (e.g., antigen equivalents); complete (i.e., HLA-A, -B, and -C)

2025 CPT code 81379

HLA Class I typing, high resolution (ie, alleles or allele groups); complete (ie, HLA-A, -B, and -C)

2025 CPT code 81163

BRCA1 and BRCA2 gene analysis; full sequence analysis.

2025 CPT code 81271

HTT (huntingtin) (e.g., Huntington disease) gene analysis; evaluation to detect abnormal (e.g., expanded) alleles

2025 CPT code 81316

PML/RARalpha,(t(15;17)), (promyelocytic leukemia/retinoic acid receptor alpha) (eg, promyelocytic leukemia) translocation analysis; single breakpoint (eg, intron 3, intron 6 or exon 6), qualitative or quantitative. (For intron 3 and intron 6 [including exon 6 if performed] analysis, use 81315). (If both intron 6 and exon 6 are analyzed, without intron 3, use one unit of 81316)

2025 CPT code 81315

PML/RARalpha,(t(15;17)), (promyelocytic leukemia/retinoic acid receptor alpha) (eg, promyelocytic leukemia) translocation analysis; common breakpoints (eg, intron 3 and intron 6), qualitative or quantitative

2025 CPT code 81275

KRAS (Kirsten rat sarcoma viral oncogene homolog) (eg, carcinoma) gene analysis; variants in exon 2 (eg, codons 12 and 13)

2025 CPT code 81380

HLA Class I typing, high resolution (ie, alleles or allele groups); one locus (eg, HLA-A, -B, or -C), each.

2025 CPT code 81402

Molecular pathology procedure, level 3.This includes analysis of >10 single nucleotide polymorphisms (SNPs), 2-10 methylated variants, 2-10 somatic variants, immunoglobulin and T-cell receptor gene rearrangements, duplication/deletion variants of one exon, loss of heterozygosity (LOH), and uniparental disomy (UPD).

2025 CPT code 81278

IGH@/BCL2 (t(14;18)) (eg, follicular lymphoma) translocation analysis, major breakpoint region (MBR) and minor cluster region (mcr) breakpoints, qualitative or quantitative.

2025 CPT code 81408

Molecular pathology procedure, Level 9 (eg, analysis of >50 exons in a single gene by DNA sequence analysis).

2025 CPT code 81107

Human Platelet Antigen 3 (HPA-3) genotyping, ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex], antigen CD41 [GPIIb]) (e.g., neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), gene analysis, common variant, HPA-3a/b (I843S)

2025 CPT code 81110

Human Platelet Antigen 6 genotyping (HPA-6w), ITGB3 (integrin, beta 3 [platelet glycoprotein IIIa, antigen CD61] [GPIIIa]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), gene analysis, common variant, HPA-6a/b (R489Q)

2025 CPT code 81106

Human Platelet Antigen 2 (HPA-2) genotyping, GP1BA (glycoprotein Ib [platelet], alpha polypeptide [GPIba]) (e.g., neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), gene analysis, common variant, HPA-2a/b (T145M).

2025 CPT code 81479

Unlisted molecular pathology procedure.

2025 CPT code 81167

BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; full duplication/deletion analysis (ie, detection of large gene rearrangements).

2025 CPT code 81171

AFF2 (ALF transcription elongation factor 2 [FMR2]) (eg, fragile X intellectual disability 2 [FRAXE]) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81188

CSTB (cystatin B) (eg, Unverricht-Lundborg disease) gene analysis; evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81172

AFF2 (ALF transcription elongation factor 2 [FMR2]) (eg, fragile X intellectual disability 2 [FRAXE]) gene analysis; characterization of alleles (eg, expanded size and methylation status).

2025 CPT code 81186

CACNA1A (calcium voltage-gated channel subunit alpha1 A) (eg, spinocerebellar ataxia) gene analysis; known familial variant

2025 CPT code 81187

CNBP (CCHC-type zinc finger nucleic acid binding protein) (eg, myotonic dystrophy type 2) gene analysis, evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81201

APC (adenomatous polyposis coli) (eg, familial adenomatosis polyposis [FAP], attenuated FAP) gene analysis; full gene sequence

2025 CPT code 81205

Branched-chain keto acid dehydrogenase E1, beta polypeptide (BCKDHB) (e.g., maple syrup urine disease) gene analysis, common variants (e.g., R183P, G278S, E422X).

2025 CPT code 81219

CALR (calreticulin) (eg, myeloproliferative disorders), gene analysis, common variants in exon 9

2025 CPT code 81218

CEBPA (CCAAT/enhancer binding protein [C/EBP], alpha) (eg, acute myeloid leukemia), gene analysis, full gene sequence.

2025 CPT code 81224

CFTR (cystic fibrosis transmembrane conductance regulator) (eg, cystic fibrosis) gene analysis; intron 8 poly-T analysis (eg, male infertility).

2025 CPT code 81217

BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; known familial variant

2025 CPT code 81227

CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) (eg, drug metabolism), gene analysis, common variants (eg, *2, *3, *5, *6)

2025 CPT code 81226

CYP2D6 (cytochrome P450, family 2, subfamily D, polypeptide 6) (e.g., drug metabolism), gene analysis, common variants (e.g., *2, *3, *4, *5, *6, *9, *10, *17, *19, *29, *35, *41, *1XN, *2XN, *4XN).

2025 CPT code 81287

MGMT (O-6-methylguanine-DNA methyltransferase) promoter methylation analysis

2025 CPT code 81253

GJB2 (gap junction protein, beta 2, 26kDa; connexin 26) (eg, nonsyndromic hearing loss) gene analysis; known familial variants

2025 CPT code 81255

HEXA (hexosaminidase A [alpha polypeptide]) (eg, Tay-Sachs disease) gene analysis, common variants (eg, 1278insTATC, 1421+1G>C, G269S).

2025 CPT code 81264

Immunoglobulin kappa light chain locus (IGK) gene rearrangement analysis to detect abnormal clonal populations (e.g., in leukemia and lymphoma, B-cell).

2025 CPT code 81303

MECP2 (methyl CpG binding protein 2) (eg, Rett syndrome) gene analysis; known familial variant

2025 CPT code 81267

Chimerism (engraftment) analysis, post transplantation specimen (e.g., hematopoietic stem cell), includes comparison to previously performed baseline analyses; without cell selection.

2025 CPT code 81276

KRAS (Kirsten rat sarcoma viral oncogene homolog) (eg, carcinoma) gene analysis; additional variant(s) (eg, codon 61, codon 146)

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