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ALL MEDICAL CODES IN CATEGORY Molecular Pathology Procedures

2025 CPT code 81273

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (eg, mastocytosis), gene analysis, D816 variant(s).

2025 CPT code 81258

HBA1/HBA2 (alpha globin 1 and alpha globin 2) gene analysis for known familial variants.

2025 CPT code 81163

BRCA1 and BRCA2 gene analysis; full sequence analysis.

2025 CPT code 81217

BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; known familial variant

2025 CPT code 81255

HEXA (hexosaminidase A [alpha polypeptide]) (eg, Tay-Sachs disease) gene analysis, common variants (eg, 1278insTATC, 1421+1G>C, G269S).

2025 CPT code 81331

Methylation analysis of SNRPN and UBE3A genes (e.g., for Prader-Willi and/or Angelman syndromes).

2025 CPT code 81232

Analysis of common variants in the dihydropyrimidine dehydrogenase (DPYD) gene (e.g., *2A, *4, *5, *6) to assess drug metabolism, primarily for 5-fluorouracil (5-FU) and capecitabine.

2025 CPT code 81246

Analysis of FLT3 gene for tyrosine kinase domain (TKD) variants.

2025 CPT code 81361

Analysis of the HBB gene for common variants (e.g., HbS, HbC, HbE).

2025 CPT code 81194

Analysis of NTRK1, NTRK2, and NTRK3 gene translocations.

2025 CPT code 81203

Analysis of the APC gene for duplication/deletion variants.

2025 CPT code 81301

Microsatellite instability analysis to detect mismatch repair deficiency, including comparison of neoplastic and normal tissue if performed.

2025 CPT code 81182

Analysis of the ATXN8OS gene to detect abnormal alleles, specifically expanded sequences, often associated with spinocerebellar ataxia 8 (SCA8).

2025 CPT code 81292

Complete gene sequencing analysis of the MLH1 gene.

2025 CPT code 81297

Analysis of the MSH2 gene for duplications and deletions.

2025 CPT code 81200

Analysis of the ASPA gene for common variants (e.g., E285A, Y231X).

2025 CPT code 81403

This CPT code represents the technical component of a Tier 2, Level 4 molecular pathology procedure.It encompasses various analyses of a single gene, including DNA sequencing, multiplex PCR, mutation scanning, or duplication/deletion variant analysis.

2025 CPT code 81296

Analysis of known familial variants in the MSH2 gene.

2025 CPT code 81111

Analysis of the common alleles of Human Platelet Antigen 9 (HPA-9) gene.

2025 CPT code 81179

ATXN2 (ataxin 2) (eg, spinocerebellar ataxia) gene analysis, evaluation to detect abnormal (eg, expanded) alleles

2025 CPT code 81381

High-resolution HLA Class I typing for a single allele or allele group.

2025 CPT code 81112

Analysis of the common alleles of Human Platelet Antigen 15 (HPA-15), also known as CD109 (CD109 molecule), using a blood or amniotic fluid specimen.

2025 CPT code 81370

HLA Class I and II typing, low resolution, molecular techniques.

2025 CPT code 81109

Analysis of common Human Platelet Antigen 5 (HPA-5) gene variants (e.g., HPA-5a/b [K505E]) using a patient specimen (e.g., blood).

2025 CPT code 81332

Analysis of common SERPINA1 gene variants (e.g., *S and *Z) associated with alpha-1-antitrypsin deficiency.

2025 CPT code 81345

Analysis of the telomerase reverse transcriptase (TERT) gene, focusing on targeted sequences like the promoter region.

2025 CPT code 81216

Analysis of the complete BRCA2 gene sequence.

2025 CPT code 81352

Targeted sequence analysis of the TP53 gene.

2025 CPT code 81279

Targeted sequence analysis of the JAK2 (Janus kinase 2) gene, focusing on exons 12 and 13, often used in myeloproliferative neoplasm (MPN) diagnostics.

2025 CPT code 81307

Analysis of the entire PALB2 gene sequence; detects variants associated with breast and pancreatic cancer risk.

2025 CPT code 81176

Analysis of a targeted gene sequence, such as exon 12, for ASXL1 (additional sex combs like 1, transcriptional regulator).

2025 CPT code 81252

Analysis of the complete GJB2 gene sequence, encompassing all exons and introns, to identify variations associated with hearing loss.

2025 CPT code 81212

Analysis of BRCA1 and BRCA2 genes for common variants (185delAG, 5385insC, 6174delT).

2025 CPT code 81265

Comparative analysis using Short Tandem Repeat (STR) markers; patient and comparative specimen (e.g., pre-transplant recipient and donor germline testing, post-transplant non-hematopoietic recipient germline [e.g., buccal swab or other germline tissue sample] and donor testing, twin zygosity testing, or maternal cell contamination of fetal cells).

2025 CPT code 81378

High-resolution HLA typing for Class I (HLA-A, -B, -C) and Class II (HLA-DRB1) using molecular techniques.

2025 CPT code 81192

Analysis of NTRK2 (neurotrophic receptor tyrosine kinase 2) gene translocations, often associated with certain solid tumors.

2025 CPT code 81400

Molecular pathology procedure, Level 1;identifies single germline variants using techniques like restriction enzyme digestion or melt curve analysis.

2025 CPT code 81233

Analysis of the Bruton's tyrosine kinase (BTK) gene for common variants (e.g., C481S, C481R, C481F).

2025 CPT code 81105

Analysis of the common HPA-1a/b alleles in the ITGB3 gene.

2025 CPT code 81166

Analysis of the BRCA1 gene for full duplication/deletion to detect large gene rearrangements.

2025 CPT code 81298

Analysis of the complete MSH6 gene sequence.

2025 CPT code 81323

PTEN (phosphatase and tensin homolog) (eg, Cowden syndrome, PTEN hamartoma tumor syndrome) gene analysis; duplication/deletion variant

2025 CPT code 81353

Analysis of known familial variants in the TP53 gene.

2025 CPT code 81269

Analysis of HBA1/HBA2 genes for duplications and deletions, associated with alpha thalassemia.

2025 CPT code 81229

Cytogenomic (genome-wide) microarray analysis for constitutional chromosomal abnormalities; interrogation of genomic regions for copy number and single nucleotide polymorphism (SNP) variants.

2025 CPT code 81355

Analysis of VKORC1 gene for common variants related to warfarin metabolism.

2025 CPT code 81210

BRAF (B-Raf proto-oncogene, serine/threonine kinase) gene analysis for V600 variant(s).

2025 CPT code 81383

HLA Class II typing, high resolution (ie, alleles or allele groups); one allele or allele group (eg, HLA-DQB1*06:02P), each

2025 CPT code 81121

IDH2 (isocitrate dehydrogenase 2 [NADP+], mitochondrial) (eg, glioma), common variants (eg, R140W, R172M).

2025 CPT code 81377

HLA Class II typing, low resolution (e.g., antigen equivalents); one antigen equivalent, each.