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HBA1/HBA2 (alpha globin 1 and alpha globin 2) gene analysis for known familial variants.
2025 CPT code 81163
BRCA1 and BRCA2 gene analysis; full sequence analysis.
2025 CPT code 81217
BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer) gene analysis; known familial variant
2025 CPT code 81255
HEXA (hexosaminidase A [alpha polypeptide]) (eg, Tay-Sachs disease) gene analysis, common variants (eg, 1278insTATC, 1421+1G>C, G269S).
2025 CPT code 81331
Methylation analysis of SNRPN and UBE3A genes (e.g., for Prader-Willi and/or Angelman syndromes).
2025 CPT code 81232
Analysis of common variants in the dihydropyrimidine dehydrogenase (DPYD) gene (e.g., *2A, *4, *5, *6) to assess drug metabolism, primarily for 5-fluorouracil (5-FU) and capecitabine.
2025 CPT code 81246
Analysis of FLT3 gene for tyrosine kinase domain (TKD) variants.
2025 CPT code 81361
Analysis of the HBB gene for common variants (e.g., HbS, HbC, HbE).
2025 CPT code 81194
Analysis of NTRK1, NTRK2, and NTRK3 gene translocations.
2025 CPT code 81203
Analysis of the APC gene for duplication/deletion variants.
2025 CPT code 81301
Microsatellite instability analysis to detect mismatch repair deficiency, including comparison of neoplastic and normal tissue if performed.
2025 CPT code 81182
Analysis of the ATXN8OS gene to detect abnormal alleles, specifically expanded sequences, often associated with spinocerebellar ataxia 8 (SCA8).
2025 CPT code 81292
Complete gene sequencing analysis of the MLH1 gene.
2025 CPT code 81297
Analysis of the MSH2 gene for duplications and deletions.
2025 CPT code 81200
Analysis of the ASPA gene for common variants (e.g., E285A, Y231X).
2025 CPT code 81403
This CPT code represents the technical component of a Tier 2, Level 4 molecular pathology procedure.It encompasses various analyses of a single gene, including DNA sequencing, multiplex PCR, mutation scanning, or duplication/deletion variant analysis.
2025 CPT code 81296
Analysis of known familial variants in the MSH2 gene.
2025 CPT code 81111
Analysis of the common alleles of Human Platelet Antigen 9 (HPA-9) gene.
High-resolution HLA Class I typing for a single allele or allele group.
2025 CPT code 81112
Analysis of the common alleles of Human Platelet Antigen 15 (HPA-15), also known as CD109 (CD109 molecule), using a blood or amniotic fluid specimen.
2025 CPT code 81370
HLA Class I and II typing, low resolution, molecular techniques.
2025 CPT code 81109
Analysis of common Human Platelet Antigen 5 (HPA-5) gene variants (e.g., HPA-5a/b [K505E]) using a patient specimen (e.g., blood).
2025 CPT code 81332
Analysis of common SERPINA1 gene variants (e.g., *S and *Z) associated with alpha-1-antitrypsin deficiency.
2025 CPT code 81345
Analysis of the telomerase reverse transcriptase (TERT) gene, focusing on targeted sequences like the promoter region.
2025 CPT code 81216
Analysis of the complete BRCA2 gene sequence.
2025 CPT code 81352
Targeted sequence analysis of the TP53 gene.
2025 CPT code 81279
Targeted sequence analysis of the JAK2 (Janus kinase 2) gene, focusing on exons 12 and 13, often used in myeloproliferative neoplasm (MPN) diagnostics.
2025 CPT code 81307
Analysis of the entire PALB2 gene sequence; detects variants associated with breast and pancreatic cancer risk.
2025 CPT code 81176
Analysis of a targeted gene sequence, such as exon 12, for ASXL1 (additional sex combs like 1, transcriptional regulator).
2025 CPT code 81252
Analysis of the complete GJB2 gene sequence, encompassing all exons and introns, to identify variations associated with hearing loss.
2025 CPT code 81212
Analysis of BRCA1 and BRCA2 genes for common variants (185delAG, 5385insC, 6174delT).
2025 CPT code 81265
Comparative analysis using Short Tandem Repeat (STR) markers; patient and comparative specimen (e.g., pre-transplant recipient and donor germline testing, post-transplant non-hematopoietic recipient germline [e.g., buccal swab or other germline tissue sample] and donor testing, twin zygosity testing, or maternal cell contamination of fetal cells).
2025 CPT code 81378
High-resolution HLA typing for Class I (HLA-A, -B, -C) and Class II (HLA-DRB1) using molecular techniques.
2025 CPT code 81192
Analysis of NTRK2 (neurotrophic receptor tyrosine kinase 2) gene translocations, often associated with certain solid tumors.
2025 CPT code 81400
Molecular pathology procedure, Level 1;identifies single germline variants using techniques like restriction enzyme digestion or melt curve analysis.
2025 CPT code 81233
Analysis of the Bruton's tyrosine kinase (BTK) gene for common variants (e.g., C481S, C481R, C481F).
2025 CPT code 81105
Analysis of the common HPA-1a/b alleles in the ITGB3 gene.
2025 CPT code 81166
Analysis of the BRCA1 gene for full duplication/deletion to detect large gene rearrangements.
Analysis of known familial variants in the TP53 gene.
2025 CPT code 81269
Analysis of HBA1/HBA2 genes for duplications and deletions, associated with alpha thalassemia.
2025 CPT code 81229
Cytogenomic (genome-wide) microarray analysis for constitutional chromosomal abnormalities; interrogation of genomic regions for copy number and single nucleotide polymorphism (SNP) variants.
2025 CPT code 81355
Analysis of VKORC1 gene for common variants related to warfarin metabolism.
2025 CPT code 81210
BRAF (B-Raf proto-oncogene, serine/threonine kinase) gene analysis for V600 variant(s).
2025 CPT code 81383
HLA Class II typing, high resolution (ie, alleles or allele groups); one allele or allele group (eg, HLA-DQB1*06:02P), each
HLA Class II typing, low resolution (e.g., antigen equivalents); one antigen equivalent, each.
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