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ALL MEDICAL CODES IN CATEGORY Multianalyte Assays with Algorithmic Analyses (MAAAs)

2025 CPT code 81541

mRNA gene expression profiling by real-time RT-PCR of 46 genes (31 content and 15 housekeeping) from formalin-fixed paraffin-embedded prostate tissue; algorithm reported as a disease-specific mortality risk score.

2025 CPT code 81535

This code represents the first single drug or drug combination analysis in a gynecological oncology live tumor cell culture, using DAPI stain and morphology for a predictive algorithm reported as a drug response score.

2025 CPT code 81546

Oncology (thyroid), mRNA, gene expression analysis of 10,196 genes, using fine needle aspirate; algorithm reported as a categorical result (e.g., benign or suspicious).

2025 CPT code 81507

Analysis of maternal plasma DNA to assess risk for fetal trisomies 13, 18, and 21, using an algorithm to generate a risk score for each trisomy.

2025 CPT code 81538

This code represents a multianalyte assay with algorithmic analysis (MAAA) for evaluating lung cancer patient survival prognosis using a serum specimen and mass spectrometry of eight proteins, including amyloid A.

2025 CPT code 81500

This code represents the Risk of Ovarian Malignancy Algorithm (ROMA) test, a multianalyte assay with algorithmic analysis (MAAA) that uses CA-125 and HE4 protein levels along with menopausal status to calculate a risk score for ovarian malignancy.

2025 CPT code 81552

mRNA gene expression profiling by real-time RT-PCR of 15 genes (12 content and 3 housekeeping) from a fine needle aspirate or formalin-fixed paraffin-embedded tissue specimen; algorithm reported as risk of uveal melanoma metastasis.

2025 CPT code 81542

mRNA gene expression profiling of 22 genes in formalin-fixed paraffin-embedded (FFPE) prostate tumor tissue; algorithmic analysis for prostate cancer metastasis risk score.

2025 CPT code 81513

Infectious disease, bacterial vaginosis; quantitative real-time amplification of RNA markers for Atopobium vaginae, Gardnerella vaginalis, and Lactobacillus species; utilizing vaginal fluid specimens; algorithm reported as a positive or negative result for bacterial vaginosis.

2025 CPT code 81521

Analysis of 70 genes using mRNA microarray, along with patient data, to determine breast cancer recurrence risk; reported as a risk score.

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