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ALL MEDICAL CODES IN CATEGORY Proprietary Laboratory Analyses

2025 CPT code 0038U

Quantitative measurement of vitamin D (25 hydroxy D2 and D3) in a microvolume serum sample using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

2025 CPT code 0167U

Gonadotropin, chorionic (hCG), immunoassay with direct optical observation, blood.

2025 CPT code 0422U

Analysis of DNA biomarker response to anti-cancer therapy using cell-free circulating DNA, comparing it to a baseline test via next-generation sequencing; algorithm reports quantitative change from baseline.

2025 CPT code 0159U

mRNA sequence analysis of the MSH2 gene; reported in addition to the code for the primary procedure.

2025 CPT code 0153U

Gene expression profiling by next-generation sequencing of 101 genes in formalin-fixed paraffin-embedded breast tumor tissue; algorithm reports triple-negative breast cancer subtype(s) and immune cell involvement.

2025 CPT code 0229U

Analysis of BCAT1 and IKZF1 gene promoter methylation; used to detect colorectal cancer residual disease or recurrence.

2025 CPT code 0183U

Red cell antigen (Diego blood group) genotyping, gene analysis, SLC4A1 exon 19.

2025 CPT code 0205U

Analysis of three gene variants (two CFH, one ARMS2) using PCR and MALDI-TOF to assess neovascular age-related macular degeneration (AMD) risk associated with zinc supplements.

2025 CPT code 0390U

This CPT code reports a serum biomarker test (PEPredictDx) to assess preeclampsia risk in pregnant women using immunoassay and an algorithm to generate a risk score.

2025 CPT code 0188U

This CPT code reports genotyping for Gerbich blood group (GE) antigens by analyzing exons 1-4 of the GYPC gene.

2025 CPT code 0087U

mRNA gene expression profiling by microarray of 1283 genes in heart transplant biopsy tissue, algorithm reported as a probability score for allograft rejection and injury.

2025 CPT code 0334U

Targeted genomic sequencing analysis of formalin-fixed paraffin-embedded (FFPE) solid tumor tissue DNA, examining 84 or more genes for variants, copy number changes, rearrangements, microsatellite instability, and tumor mutational burden.

2025 CPT code 0382U

This CPT code reports a Mayo Clinic phenylalanine and tyrosine blood spot test using LC-MS/MS.

2025 CPT code 0029U

Targeted sequence analysis for drug metabolism, focusing on genes related to adverse drug reactions and drug response (CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, CYP4F2, SLCO1B1, VKORC1, and rs12777823).

2025 CPT code 0378U

RFC1 gene repeat expansion variant analysis using PCR on blood, saliva, or buccal swab specimens.

2025 CPT code 0359U

Analysis of all prostate-specific antigen (PSA) structural isoforms using phase separation and immunoassay; plasma; algorithm reports cancer risk.

2025 CPT code 0002U

Quantitative assessment of three urine metabolites (ascorbic acid, succinic acid, and carnitine) by liquid chromatography with tandem mass spectrometry (LC-MS/MS), algorithm reported as likelihood of adenomatous polyps.

2025 CPT code 0249U

Semi-quantitative analysis of 32 phosphoproteins and protein analytes in breast tumor tissue, using laser capture microdissection and reverse-phase protein array (RPPA) technology, with algorithmic analysis and interpretive report.

2025 CPT code +0073U

CYP2D6 gene analysis, targeted sequence analysis (CYP2D7-2D6 hybrid gene), performed as a follow-up test when initial testing does not determine the patient's CYP2D6 genotype.

2025 CPT code 0178U

This CPT code represents the VeriMAP™ Peanut Sensitivity – Bead-based Epitope Assay, a blood test assessing multiple peanut allergen epitopes to determine the minimum protein dose causing an allergic reaction.

2025 CPT code 0113U

Measurement of PCA3 and TMPRSS2-ERG in urine and PSA in serum, following prostatic massage, using RNA amplification and fluorescence-based detection; algorithm reported as a risk score.

2025 CPT code 0042U

This CPT code represents IGeneX Inc.'s Lyme ImmunoBlot IgG test, detecting IgG antibodies to 12 Borrelia burgdorferi recombinant protein groups.

2025 CPT code +0076U

CYP2D6 gene analysis, targeted sequence analysis for 3' gene duplication/multiplication; add-on code.

2025 CPT code 0320U

Post-kidney transplant blood test using next-generation sequencing to assess the risk of acute cellular rejection.

2025 CPT code 0027U

JAK2 Exons 12-15 Sequencing (JAKXR) analysis; a proprietary algorithm distinguishes myeloproliferative neoplasm polycythemia vera from other erythrocytoses.

2025 CPT code 0052U

High-resolution lipoprotein fractionation and quantitation, including all five major lipoprotein classes and subclasses of HDL, LDL, and VLDL, using vertical auto profile ultracentrifugation.

2025 CPT code 0228U

PanGIA Prostate test analyzes urine biomarkers to assess prostate cancer risk.

2025 CPT code 0095U

Analysis of eotaxin-3 and major basic protein via ELISA, specimen from esophageal string test, algorithm reports probability of active eosinophilic esophagitis.

2025 CPT code 0023U

This CPT code, 0023U, represents the LeukoStrat® CDx FLT3 Mutation Assay, a molecular pathology test identifying FLT3 gene mutations in acute myeloid leukemia (AML) patients to guide treatment decisions.

2025 CPT code 0007U

Presumptive urine drug screen with confirmation of positive results, including DNA authentication of the urine sample against a buccal swab.

2025 CPT code 0062U

Autoantibody profiling test for SLE risk assessment using serum analysis of 80 biomarkers and an algorithm to generate a risk score.

2025 CPT code 0235U

Genomic Unity® PTEN Analysis; evaluates the PTEN gene for variants relevant to conditions like hamartoma tumor syndrome.

2025 CPT code 0003U

Biochemical assay of serum for five ovarian cancer biomarkers (apolipoprotein A-1, CA 125 II, FSH, HE4, transferrin) with algorithmic analysis to determine ovarian cancer risk.

2025 CPT code 0380U

Targeted sequence analysis for 20 gene variants and CYP2D6 deletion or duplication, assessing drug metabolism, adverse drug reactions, and drug response.

2025 CPT code +0072U

CYP2D6-2D7 hybrid gene targeted sequence analysis; a follow-up test when initial CYP2D6 genotyping is inconclusive.

2025 CPT code 0253U

Endometrial Receptivity Analysis (ERA) test using next-generation sequencing to evaluate RNA expression in an endometrial biopsy, aiding in determining optimal embryo transfer timing in ART.

2025 CPT code 0080U

Mass spectrometric analysis of galectin-3-binding protein and scavenger receptor cysteine-rich type 1 protein M130 in plasma, with five clinical risk factors (age, smoking status, nodule diameter, nodule spiculation status, and nodule location), algorithm reported as a categorical probability of malignancy.

2025 CPT code 0201U

Red cell antigen (Yt blood group) genotyping (YT), gene analysis, ACHE (acetylcholinesterase [Cartwright blood group]) exon 2.

2025 CPT code 0110U

Quantitative analysis of one or more oral oncology drugs and substances in serum or plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

2025 CPT code 0421U

This code represents a fecal-based colorectal cancer screening test that analyzes the expression of eight genes and fecal hemoglobin, providing a positive or negative risk assessment for colorectal cancer.

2025 CPT code 0318U

Whole genome methylation analysis by microarray for 50 or more genes using a blood sample to identify congenital epigenetic disorders in pediatric patients.

2025 CPT code 0233U

Genomic Unity® FXN Analysis evaluates the frataxin (FXN) gene for variants related to conditions like Friedreich's ataxia using WGS.

2025 CPT code 0425U

Rapid whole genome sequencing analysis of a comparator genome (e.g., parent or sibling) to identify genetic variants in a symptomatic patient.

2025 CPT code 0399U

Enzyme-linked immunosorbent assay (ELISA) to detect anti-human folate receptor IgG binding antibody and blocking autoantibodies in serum, associated with folate metabolism and potentially indicating cerebral folate deficiency.

2025 CPT code 0245U

Thyroid oncogene panel analysis using next-generation sequencing (NGS) to assess malignancy risk in indeterminate thyroid fine needle aspiration (FNA) specimens.

2025 CPT code 0394U

Quantitative measurement of 16 perfluoroalkyl substances (PFAS) compounds in serum or plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

2025 CPT code 0252U

Fetal aneuploidy analysis using next-generation sequencing (NGS) and short tandem repeat (STR) analysis on fetal DNA from products of conception.

2025 CPT code 0131U

Targeted mRNA sequence analysis panel (13 genes) for hereditary breast cancer-related disorders; reported in addition to the primary procedure code.

2025 CPT code 0021U

Apifiny®, a serum test using immunoassay and flow cytometry to detect eight autoantibodies, with an algorithm generating a prostate cancer risk score.

2025 CPT code 0319U

Pre-kidney transplant testing using next-generation sequencing (NGS) of specific parts of the transcriptome to evaluate gene expression related to immune response, resulting in a risk score for early acute rejection.