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ALL MEDICAL CODES IN CATEGORY Proprietary Laboratory Analyses

2025 CPT code 0038U

Quantitative measurement of vitamin D (25 hydroxy D2 and D3) in a microvolume serum sample using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

2025 CPT code 0121U

Flow adhesion of whole blood on VCAM-1 (FAB-V).

2025 CPT code 0031U

CYP1A2 (cytochrome P450 family 1, subfamily A, member 2) gene analysis, common variants.

2025 CPT code 0005U

Oncology (prostate) gene expression profile by real-time RT-PCR of 3 genes (ERG, PCA3, and SPDEF), urine, algorithm reported as risk score.

2025 CPT code 0086U

Infectious disease (bacterial and fungal), organism identification, blood culture, using rRNA FISH, 6 or more organism targets, reported as positive or negative with phenotypic minimum inhibitory concentration (MIC)-based antimicrobial susceptibility.

2025 CPT code 0167U

Gonadotropin, chorionic (hCG), immunoassay with direct optical observation, blood.

2025 CPT code 0140U

Infectious disease (fungi), fungal pathogen identification, DNA (15 fungal targets), blood culture, amplified probe technique, each target reported as detected or not detected.

2025 CPT code 0094U

Rapid sequence analysis of genome for unexplained constitutional or heritable disorder or syndrome.

2025 CPT code 0154U

Oncology (urothelial cancer), RNA analysis by real-time RT-PCR of the FGFR3 gene for specific mutations, using formalin-fixed paraffin-embedded urothelial cancer tumor tissue, reported as FGFR gene alteration status.

2025 CPT code 0155U

PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) gene analysis for breast cancer, using formalin-fixed paraffin-embedded breast tumor tissue, to detect mutations, reported as PIK3CA gene mutation status.

2025 CPT code 0103U

Hereditary ovarian cancer (e.g., hereditary ovarian cancer, hereditary endometrial cancer), genomic sequence analysis panel utilizing a combination of NGS, Sanger, MLPA, and array CGH, with mRNA analytics to resolve variants of unknown significance when indicated (24 genes [sequencing and deletion/duplication], EPCAM [deletion/duplication only]).

2025 CPT code 0185U

Red cell antigen (H blood group) genotyping (FUT1), gene analysis, FUT1 (fucosyltransferase 1 [H blood group]) exon 4

2025 CPT code 0388U

Next-generation sequencing (NGS) analysis of 37 cancer-related genes in plasma for non-small cell lung cancer (NSCLC) patients, identifying single nucleotide variants, copy number variants, insertions/deletions, and structural variants, to aid in treatment decisions.

2025 CPT code 0393U

Neurology (e.g., Parkinson disease, dementia with Lewy bodies), cerebrospinal fluid (CSF), detection of misfolded α-synuclein protein by seed amplification assay, qualitative.

2025 CPT code 0133U

Hereditary prostate cancer-related disorders, targeted mRNA sequence analysis panel (11 genes). This test is performed in addition to the primary procedure.

2025 CPT code 0156U

Copy number sequence analysis for detecting genetic variations associated with physical and mental developmental disorders.

2025 CPT code 0033U

Serotonin Receptor Genotype (HTR2A and HTR2C) (e.g., citalopram metabolism) gene analysis, common variants (i.e., HTR2A rs7997012 [c.614-2211T>C], HTR2C rs3813929 [c.-759C>T] and rs1414334 [c.551-3008C>G]).

2025 CPT code 0032U

COMT (catechol-O-methyltransferase) (eg, drug metabolism) gene analysis, c.472G>A (rs4680) variant

2025 CPT code 0108U

Gastroenterology (Barrett's esophagus), whole slide-digital imaging, including morphometric analysis, computer-assisted quantitative immunolabeling of 9 protein biomarkers (p16, AMACR, p53, CD68, COX-2, CD45RO, HIF1a, HER-2, K20) and morphology, formalin-fixed paraffin-embedded tissue, algorithm reported as risk of progression to high-grade dysplasia or cancer.

2025 CPT code 0101U

Hereditary colon cancer disorders (e.g., Lynch syndrome, PTEN hamartoma syndrome, Cowden syndrome, familial adenomatosis polyposis), genomic sequence analysis panel utilizing a combination of NGS, Sanger, MLPA, and array CGH, with mRNA analytics to resolve variants of unknown significance when indicated (15 genes [sequencing and deletion/duplication], EPCAM and GREM1 [deletion/duplication only]).

2025 CPT code 0247U

Obstetrics (preterm birth), insulin-like growth factor-binding protein 4 (IBP4), sex hormone-binding globulin (SHBG), quantitative measurement by LC-MS/MS, utilizing maternal serum, combined with clinical data, reported as predictive-risk stratification for spontaneous preterm birth.

2025 CPT code 0428U

Oncology (breast), targeted hybrid-capture genomic sequence analysis panel, circulating tumor DNA (ctDNA) analysis of 56 or more genes, interrogation for sequence variants, gene copy number amplifications, gene rearrangements, microsatellite instability, and tumor mutation burden

2025 CPT code 0434U

Drug metabolism (adverse drug reactions and drug response), genomic analysis panel, variant analysis of 25 genes with reported phenotypes.

2025 CPT code 0170U

Clarifi™ ASD test from Quadrant Biosciences, Inc., a saliva-based RNA analysis with algorithmic assessment for autism spectrum disorder (ASD) prediction.

2025 CPT code 0169U

NUDT15 (nudix hydrolase 15) and TPMT (thiopurine S-methyltransferase) (e.g., drug metabolism) gene analysis, common variants

2025 CPT code 0435U

Chemotherapeutic drug cytotoxicity assay of cancer stem cells (CSCs), from cultured CSCs and primary tumor cells. Categorical drug response reported based on cytotoxicity percentage observed, minimum of 14 drugs or drug combinations.

2025 CPT code 0084U

Red blood cell antigen typing, DNA, genotyping of 10 blood groups with phenotype prediction of 37 red blood cell antigens.

2025 CPT code 0371U

Detection of 16 bacterial and 1 fungal organisms in urine by multiplex amplified probe technique via qPCR.

2025 CPT code 0196U

Red cell antigen (Lutheran blood group) genotyping (LU), gene analysis, BCAM (basal cell adhesion molecule [Lutheran blood group]) exon 3

2025 CPT code 0182U

Red cell antigen (Cromer blood group) genotyping (CROM), gene analysis, CD55 (CD55 molecule [Cromer blood group]) exons 1-10

2025 CPT code 0194U

Red cell antigen (Kell blood group) genotyping (KEL), gene analysis, KEL (Kell metallo-endopeptidase [Kell blood group]) exon 8

2025 CPT code 0204U

Oncology (thyroid), mRNA, gene expression analysis of 593 genes (including BRAF, RAS, RET, PAX8, and NTRK) for sequence variants and rearrangements, utilizing fine needle aspirate, reported as detected or not detected.

2025 CPT code 0209U

Cytogenomic constitutional (genome-wide) analysis for chromosomal abnormalities.

2025 CPT code 0187U

Red cell antigen (Duffy blood group) genotyping (FY), gene analysis, ACKR1 (atypical chemokine receptor 1 [Duffy blood group]) exons 1-2

2025 CPT code 0045U

Oncology (breast ductal carcinoma in situ), mRNA, gene expression profiling by real-time RT-PCR of 12 genes (7 content and 5 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as recurrence score.

2025 CPT code 0337U

Oncology (plasma cell disorders and myeloma), circulating plasma cell immunologic selection, identification, morphological characterization, and enumeration of plasma cells based on differential CD138, CD38, CD19, and CD45 protein biomarker expression, peripheral blood.

2025 CPT code 0164U

Irritable bowel syndrome (IBS) immunoassay for anti-CdtB and anti-vinculin antibodies, plasma, algorithm for elevated or not elevated qualitative results.

2025 CPT code 0018U

ThyraMIR™ Thyroid microRNA Classifier.This test analyzes 10 microRNA sequences from a thyroid fine needle aspirate (FNA) using RT-PCR, along with patient data and an algorithm, to assess the risk of malignancy.

2025 CPT code 0082U

Drug test(s), definitive, 90 or more drugs or substances, definitive chromatography with mass spectrometry, and presumptive, any number of drug classes, by instrument chemistry analyzer (utilizing immunoassay), urine; report of presence or absence of each drug, drug metabolite or substance with description and severity of significant interactions per date of service.

2025 CPT code 0017U

Oncology (hematolymphoid neoplasia), JAK2 mutation, DNA, PCR amplification of exons 12-14 and sequence analysis, blood or bone marrow, report of JAK2 mutation not detected or detected.

2025 CPT code 0011U

Prescription drug monitoring, evaluation of drugs present by LC-MS/MS, using oral fluid, reported as a comparison to an estimated steady-state range, per date of service including all drug compounds and metabolites.

2025 CPT code 0105U

KidneyIntelX™ test from RenalytixAI, which combines immunoassay results for tumor necrosis factors and kidney injury molecule–1 with clinical data and provides a score predicting the probability of rapid kidney function decline.

2025 CPT code 0109U

MycoDART-PCR™ Aspergillus diagnostic panel, qualitative reporting of presence or absence of each species.

2025 CPT code 0035U

Neurology (prion disease), cerebrospinal fluid, detection of prion protein by quaking-induced conformational conversion, qualitative.

2025 CPT code 0036U

Exome (i.e., somatic mutations), paired formalin-fixed paraffin-embedded tumor tissue and normal specimen, sequence analyses.

2025 CPT code 0130U

Targeted mRNA sequence analysis panel of 10 genes (APC, CDH1, CHEK2, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, and TP53) for hereditary colon cancer disorders.

2025 CPT code 0026U

Oncology (thyroid), DNA and mRNA of 112 genes, next-generation sequencing, fine needle aspirate of thyroid nodule, algorithmic analysis reported as a categorical result (Positive, high probability of malignancy or Negative, low probability of malignancy).

2025 CPT code 0241U

This test detects and differentiates four respiratory viruses: SARS-CoV-2, influenza A, influenza B, and RSV, from an upper respiratory specimen. It reports whether each virus is detected or not detected.

2025 CPT code 0008U

Helicobacter pylori detection and antibiotic resistance, DNA, 16S and 23S rRNA, gyrA, pbp1, rdxA and rpoB, next generation sequencing, formalin-fixed paraffin-embedded or fresh tissue or fecal sample, predictive, reported as positive or negative for resistance to clarithromycin, fluoroquinolones, metronidazole, amoxicillin, tetracycline, and rifabutin.

2025 CPT code 0361U

Neurofilament light chain (NfL) analysis in plasma using a digital immunoassay technique to aid in evaluating neurodegenerative disease.