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ALL MEDICAL CODES IN CATEGORY Proprietary Laboratory Analyses
2025 CPT code 0038U
Quantitative measurement of vitamin D (25 hydroxy D2 and D3) in a microvolume serum sample using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
2025 CPT code 0167U
Gonadotropin, chorionic (hCG), immunoassay with direct optical observation, blood.
Next-generation sequencing (NGS) analysis of 37 cancer-related genes in plasma for non-small cell lung cancer (NSCLC) patients, identifying single nucleotide variants, copy number variants, insertions/deletions, and structural variants, to aid in treatment decisions.
2025 CPT code 0393U
Neurology (e.g., Parkinson disease, dementia with Lewy bodies), cerebrospinal fluid (CSF), detection of misfolded α-synuclein protein by seed amplification assay, qualitative.
2025 CPT code 0133U
Hereditary prostate cancer-related disorders, targeted mRNA sequence analysis panel (11 genes). This test is performed in addition to the primary procedure.
2025 CPT code 0156U
Copy number sequence analysis for detecting genetic variations associated with physical and mental developmental disorders.
2025 CPT code 0033U
Serotonin Receptor Genotype (HTR2A and HTR2C) (e.g., citalopram metabolism) gene analysis, common variants (i.e., HTR2A rs7997012 [c.614-2211T>C], HTR2C rs3813929 [c.-759C>T] and rs1414334 [c.551-3008C>G]).
2025 CPT code 0032U
COMT (catechol-O-methyltransferase) (eg, drug metabolism) gene analysis, c.472G>A (rs4680) variant
2025 CPT code 0108U
Gastroenterology (Barrett's esophagus), whole slide-digital imaging, including morphometric analysis, computer-assisted quantitative immunolabeling of 9 protein biomarkers (p16, AMACR, p53, CD68, COX-2, CD45RO, HIF1a, HER-2, K20) and morphology, formalin-fixed paraffin-embedded tissue, algorithm reported as risk of progression to high-grade dysplasia or cancer.
2025 CPT code 0101U
Hereditary colon cancer disorders (e.g., Lynch syndrome, PTEN hamartoma syndrome, Cowden syndrome, familial adenomatosis polyposis), genomic sequence analysis panel utilizing a combination of NGS, Sanger, MLPA, and array CGH, with mRNA analytics to resolve variants of unknown significance when indicated (15 genes [sequencing and deletion/duplication], EPCAM and GREM1 [deletion/duplication only]).
2025 CPT code 0247U
Obstetrics (preterm birth), insulin-like growth factor-binding protein 4 (IBP4), sex hormone-binding globulin (SHBG), quantitative measurement by LC-MS/MS, utilizing maternal serum, combined with clinical data, reported as predictive-risk stratification for spontaneous preterm birth.
2025 CPT code 0428U
Oncology (breast), targeted hybrid-capture genomic sequence analysis panel, circulating tumor DNA (ctDNA) analysis of 56 or more genes, interrogation for sequence variants, gene copy number amplifications, gene rearrangements, microsatellite instability, and tumor mutation burden
2025 CPT code 0434U
Drug metabolism (adverse drug reactions and drug response), genomic analysis panel, variant analysis of 25 genes with reported phenotypes.
2025 CPT code 0170U
Clarifi™ ASD test from Quadrant Biosciences, Inc., a saliva-based RNA analysis with algorithmic assessment for autism spectrum disorder (ASD) prediction.
2025 CPT code 0169U
NUDT15 (nudix hydrolase 15) and TPMT (thiopurine S-methyltransferase) (e.g., drug metabolism) gene analysis, common variants
2025 CPT code 0435U
Chemotherapeutic drug cytotoxicity assay of cancer stem cells (CSCs), from cultured CSCs and primary tumor cells. Categorical drug response reported based on cytotoxicity percentage observed, minimum of 14 drugs or drug combinations.
2025 CPT code 0084U
Red blood cell antigen typing, DNA, genotyping of 10 blood groups with phenotype prediction of 37 red blood cell antigens.
2025 CPT code 0371U
Detection of 16 bacterial and 1 fungal organisms in urine by multiplex amplified probe technique via qPCR.
Red cell antigen (Kell blood group) genotyping (KEL), gene analysis, KEL (Kell metallo-endopeptidase [Kell blood group]) exon 8
2025 CPT code 0204U
Oncology (thyroid), mRNA, gene expression analysis of 593 genes (including BRAF, RAS, RET, PAX8, and NTRK) for sequence variants and rearrangements, utilizing fine needle aspirate, reported as detected or not detected.
2025 CPT code 0209U
Cytogenomic constitutional (genome-wide) analysis for chromosomal abnormalities.
Oncology (breast ductal carcinoma in situ), mRNA, gene expression profiling by real-time RT-PCR of 12 genes (7 content and 5 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as recurrence score.
2025 CPT code 0337U
Oncology (plasma cell disorders and myeloma), circulating plasma cell immunologic selection, identification, morphological characterization, and enumeration of plasma cells based on differential CD138, CD38, CD19, and CD45 protein biomarker expression, peripheral blood.
2025 CPT code 0164U
Irritable bowel syndrome (IBS) immunoassay for anti-CdtB and anti-vinculin antibodies, plasma, algorithm for elevated or not elevated qualitative results.
2025 CPT code 0018U
ThyraMIR™ Thyroid microRNA Classifier.This test analyzes 10 microRNA sequences from a thyroid fine needle aspirate (FNA) using RT-PCR, along with patient data and an algorithm, to assess the risk of malignancy.
2025 CPT code 0082U
Drug test(s), definitive, 90 or more drugs or substances, definitive chromatography with mass spectrometry, and presumptive, any number of drug classes, by instrument chemistry analyzer (utilizing immunoassay), urine; report of presence or absence of each drug, drug metabolite or substance with description and severity of significant interactions per date of service.
2025 CPT code 0017U
Oncology (hematolymphoid neoplasia), JAK2 mutation, DNA, PCR amplification of exons 12-14 and sequence analysis, blood or bone marrow, report of JAK2 mutation not detected or detected.
2025 CPT code 0011U
Prescription drug monitoring, evaluation of drugs present by LC-MS/MS, using oral fluid, reported as a comparison to an estimated steady-state range, per date of service including all drug compounds and metabolites.
2025 CPT code 0105U
KidneyIntelX™ test from RenalytixAI, which combines immunoassay results for tumor necrosis factors and kidney injury molecule–1 with clinical data and provides a score predicting the probability of rapid kidney function decline.
2025 CPT code 0109U
MycoDART-PCR™ Aspergillus diagnostic panel, qualitative reporting of presence or absence of each species.
2025 CPT code 0035U
Neurology (prion disease), cerebrospinal fluid, detection of prion protein by quaking-induced conformational conversion, qualitative.
2025 CPT code 0036U
Exome (i.e., somatic mutations), paired formalin-fixed paraffin-embedded tumor tissue and normal specimen, sequence analyses.
2025 CPT code 0130U
Targeted mRNA sequence analysis panel of 10 genes (APC, CDH1, CHEK2, MLH1, MSH2, MSH6, MUTYH, PMS2, PTEN, and TP53) for hereditary colon cancer disorders.
2025 CPT code 0026U
Oncology (thyroid), DNA and mRNA of 112 genes, next-generation sequencing, fine needle aspirate of thyroid nodule, algorithmic analysis reported as a categorical result (Positive, high probability of malignancy or Negative, low probability of malignancy).
2025 CPT code 0241U
This test detects and differentiates four respiratory viruses: SARS-CoV-2, influenza A, influenza B, and RSV, from an upper respiratory specimen. It reports whether each virus is detected or not detected.
2025 CPT code 0008U
Helicobacter pylori detection and antibiotic resistance, DNA, 16S and 23S rRNA, gyrA, pbp1, rdxA and rpoB, next generation sequencing, formalin-fixed paraffin-embedded or fresh tissue or fecal sample, predictive, reported as positive or negative for resistance to clarithromycin, fluoroquinolones, metronidazole, amoxicillin, tetracycline, and rifabutin.
2025 CPT code 0361U
Neurofilament light chain (NfL) analysis in plasma using a digital immunoassay technique to aid in evaluating neurodegenerative disease.
2025 CPT code 0048U
MSK-IMPACT™ (Integrated Mutation Profiling of Actionable Cancer Targets) test for solid organ neoplasia. Analyzes 468 cancer-associated genes for somatic mutations and microsatellite instability using targeted DNA sequencing.
2025 CPT code 0049U
NPM1 (nucleophosmin) gene analysis, quantitative.
2025 CPT code 0158U
MLH1 (mutL homolog 1) (e.g., hereditary non-polyposis colorectal cancer, Lynch syndrome) mRNA sequence analysis (List separately in addition to code for primary procedure)
2025 CPT code 0041U
Borrelia burgdorferi, antibody detection of 5 recombinant protein groups, by immunoblot, IgM.
2025 CPT code 0067U
Oncology (breast), immunohistochemistry, protein expression profiling of 4 biomarkers (matrix metalloproteinase-1 [MMP-1], carcinoembryonic antigen-related cell adhesion molecule 6 [CEACAM6], hyaluronoglucosaminidase [HYAL1], highly expressed in cancer protein [HEC1]), formalin-fixed paraffin-embedded precancerous breast tissue, algorithm reported as carcinoma risk score.
2025 CPT code 0044U
Tick-borne relapsing fever (TBRF) Borrelia group, antibody detection to 4 recombinant protein groups, by immunoblot, IgG.
2025 CPT code 0077U
M-Protein Detection and Isotyping by MALDI-TOF Mass Spectrometry. This test isolates and identifies monoclonal (M-) proteins in blood or urine to aid in diagnosing monoclonal gammopathy.
2025 CPT code 0064U
Antibody, Treponema pallidum, total and rapid plasma reagin (RPR), immunoassay, qualitative.
2025 CPT code 0078U
Pain management (opioid-use disorder) genotyping panel, 16 common variants (ie, ABCB1, COMT, DAT1, DBH, DOR, DRD1, DRD2, DRD4, GABA, GAL, HTR2A, HTTLPR, MTHFR, MUOR, OPRK1, OPRM1), buccal swab or other germline tissue sample, algorithm reported as positive or negative risk of opioid-use disorder.
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