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ALL MEDICAL CODES IN CATEGORY Tier 1 Molecular Pathology Procedures; Genetic Analysis Procedures
2025 CPT code 81361
Analysis of the HBB gene for common variants (e.g., HbS, HbC, HbE).
2025 CPT code 81297
Analysis of the MSH2 gene for duplications and deletions.
2025 CPT code 81332
Analysis of common SERPINA1 gene variants (e.g., *S and *Z) associated with alpha-1-antitrypsin deficiency.
2025 CPT code 81345
Analysis of the telomerase reverse transcriptase (TERT) gene, focusing on targeted sequences like the promoter region.
2025 CPT code 81216
Analysis of the complete BRCA2 gene sequence.
2025 CPT code 81307
Analysis of the entire PALB2 gene sequence; detects variants associated with breast and pancreatic cancer risk.
2025 CPT code 81166
Analysis of the BRCA1 gene for full duplication/deletion to detect large gene rearrangements.
2025 CPT code 81189
Analysis of the full cystatin B gene (CSTB) sequence.
2025 CPT code 81268
Post-transplant chimerism analysis comparing a post-transplant specimen (e.g., bone marrow) to a baseline analysis, including lineage-specific cell subset testing (e.g., CD3, CD33).
2025 CPT code 81300
Analysis of the MSH6 gene for duplications and deletions.
2025 CPT code 81161
Analysis of deletions and duplications in the dystrophin gene (DMD), associated with Duchenne and Becker muscular dystrophy.
2025 CPT code 81302
Analysis of the full sequence of the MECP2 gene.
2025 CPT code 81347
Analysis of common variants in the SF3B1 gene, associated with myelodysplastic syndrome and acute myeloid leukemia.
2025 CPT code 81120
Analysis of common variants in the IDH1 gene, including R132H and R132C,typically used in glioma diagnosis.
2025 CPT code 81108
This code represents Human Platelet Antigen 4 (HPA-4) genotyping, analyzing common variants HPA-4a/b (R143Q) in the ITGB3 gene.The test aids in diagnosing conditions such as neonatal alloimmune thrombocytopenia (NAIT).
2025 CPT code 81301
Microsatellite instability analysis to detect mismatch repair deficiency, including comparison of neoplastic and normal tissue if performed.
2025 CPT code 81342
Analysis of T-cell receptor gamma (TRG) gene rearrangements to detect abnormal clonal T-cell populations, which may indicate leukemia or lymphoma.
2025 CPT code 81261
Analysis of immunoglobulin heavy chain locus (IGH@) gene rearrangement to identify abnormal clonal populations, using amplified methodologies like PCR.
2025 CPT code 81162
Analysis of BRCA1 and BRCA2 genes; full sequence and duplication/deletion analysis.
2025 CPT code 81333
Analysis of the transforming growth factor beta-induced gene (TGFBI), common variants (e.g., R124H, R124C, R124L, R555W, R555Q).
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