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ALL MEDICAL CODES IN CATEGORY Tier 1 Molecular Pathology Procedures, Genetic Analysis Procedures
2025 CPT code 81265
Comparative analysis using Short Tandem Repeat (STR) markers; patient and comparative specimen (e.g., pre-transplant recipient and donor germline testing, post-transplant non-hematopoietic recipient germline [e.g., buccal swab or other germline tissue sample] and donor testing, twin zygosity testing, or maternal cell contamination of fetal cells).
2025 CPT code 81192
Analysis of NTRK2 (neurotrophic receptor tyrosine kinase 2) gene translocations, often associated with certain solid tumors.
2025 CPT code 81236
Analysis of the entire EZH2 gene sequence.
2025 CPT code 81311
Analysis of NRAS gene variants in exons 2 and 3.
2025 CPT code 81331
Methylation analysis of SNRPN and UBE3A genes (e.g., for Prader-Willi and/or Angelman syndromes).
2025 CPT code 81232
Analysis of common variants in the dihydropyrimidine dehydrogenase (DPYD) gene (e.g., *2A, *4, *5, *6) to assess drug metabolism, primarily for 5-fluorouracil (5-FU) and capecitabine.
2025 CPT code 81194
Analysis of NTRK1, NTRK2, and NTRK3 gene translocations.
2025 CPT code 81259
Full gene sequence analysis of HBA1/HBA2 genes (alpha globin 1 and alpha globin 2) related to alpha thalassemia and some hemoglobinopathies.
2025 CPT code 81164
BRCA1 and BRCA2 gene analysis; full duplication/deletion analysis.
2025 CPT code 81257
Analysis of HBA1/HBA2 genes (alpha globin 1 and 2) for common deletions or variants associated with alpha thalassemia and other hemoglobinopathies.
2025 CPT code 81242
Analysis of the FANCC gene for common variants, such as IVS4+4A>T, associated with Fanconi anemia.
2025 CPT code 81229
Cytogenomic (genome-wide) microarray analysis for constitutional chromosomal abnormalities; interrogation of genomic regions for copy number and single nucleotide polymorphism (SNP) variants.
2025 CPT code 81362
Analysis of the HBB gene for known familial variants.
2025 CPT code 81338
Analysis of common MPL gene variants (e.g., W515A, W515K, W515L, W515R) associated with myeloproliferative neoplasms.
2025 CPT code 81326
Analysis of the PMP22 gene for known familial variants associated with conditions like Charcot-Marie-Tooth disease and hereditary neuropathy with liability to pressure palsies.
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