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ALL MEDICAL CODES IN CATEGORY Tier 1 Molecular Pathology Procedures

2025 CPT code 81375

HLA Class II typing, low resolution (HLA-DRB1/3/4/5 and -DQB1).

2025 CPT code 81328

Analysis of the SLCO1B1 gene for common variants (e.g., *5).

2025 CPT code 81373

Low-resolution HLA Class I typing for one locus (HLA-A, -B, or -C).

2025 CPT code 81279

Targeted sequence analysis of the JAK2 (Janus kinase 2) gene, focusing on exons 12 and 13, often used in myeloproliferative neoplasm (MPN) diagnostics.

2025 CPT code 81382

High-resolution HLA Class II typing for one locus.

2025 CPT code 81321

Complete gene sequencing analysis of the PTEN gene.

2025 CPT code 81202

Analysis of known familial variants in the adenomatous polyposis coli (APC) gene.

2025 CPT code 81370

HLA Class I and II typing, low resolution, molecular techniques.

2025 CPT code 81252

Analysis of the complete GJB2 gene sequence, encompassing all exons and introns, to identify variations associated with hearing loss.

2025 CPT code 81320

Analysis of common variants in the PLCG2 gene.

2025 CPT code 81317

Analysis of the entire PMS2 gene sequence.

2025 CPT code 81294

MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2) (eg, hereditary non-polyposis colorectal cancer, Lynch syndrome) gene analysis; duplication/deletion variants

2025 CPT code 81371

Low or intermediate resolution HLA typing for HLA-A, -B, and -DRB1 loci.

2025 CPT code 81381

High-resolution HLA Class I typing for a single allele or allele group.

2025 CPT code 81378

High-resolution HLA typing for Class I (HLA-A, -B, -C) and Class II (HLA-DRB1) using molecular techniques.

2025 CPT code 81312

Analysis of the PABPN1 gene to detect abnormal alleles, often used in diagnosing oculopharyngeal muscular dystrophy (OPMD).

2025 CPT code 81239

Characterization of DMPK gene alleles (e.g., expanded size) for conditions like myotonic dystrophy type 1.

2025 CPT code 81220

Analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene for common variants, typically using ACMG/ACOG guidelines.

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