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BETA v.3.0

2025 CPT code 36450

Exchange transfusion, blood; newborn.

Do not report modifier 63 with 36450. For partial exchange transfusions, use 36456. For automated red cell exchange, use 36512.

Modifiers may be applicable in certain situations, such as 52 for reduced services or 73/74 for discontinued procedures.

Medical necessity for exchange transfusion is based on the newborn's clinical condition.High bilirubin levels, blood type incompatibility, or severe infections may necessitate the procedure to improve the newborn's health and prevent complications.

The physician prepares the newborn, accesses the umbilical vein, inserts a catheter, and performs the exchange transfusion.The procedure involves multiple cycles of withdrawing the newborn's blood and replacing it with donor blood. The physician then removes the catheter and ensures bleeding is stopped.

IMPORTANT:(When a partial exchange transfusion is performed in a newborn, use 36456) (Do not report modifier 63 in conjunction with 36450) (For manual red cell exchange, see 36450, 36455, 36456) (For automated red cell exchange, use 36512)

In simple words: This procedure is done on newborns to treat severe jaundice.The doctor slowly removes a small amount of the baby's blood and replaces it with the same amount of healthy donor blood. This helps to lower the levels of bilirubin, a substance that causes jaundice.

This procedure involves the exchange of blood in a newborn.It is commonly performed to treat severe cases of jaundice by removing bilirubin from the blood and replacing it with healthy donor blood or plasma.

Example 1: A newborn with severe jaundice and high bilirubin levels requires an exchange transfusion to prevent kernicterus., A newborn with Rh incompatibility undergoes an exchange transfusion to remove antibodies attacking red blood cells., A newborn with sepsis and disseminated intravascular coagulation requires an exchange transfusion to remove toxins and improve blood clotting factors.

Documentation should include the reason for the exchange transfusion (e.g., jaundice, Rh incompatibility), the volume of blood exchanged, the type of donor blood/plasma used, and any complications encountered.

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