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2025 CPT code 48102

Percutaneous needle biopsy of the pancreas.

Code 48102 is reported only once per procedure, regardless of the number of samples taken.

Modifiers may be applicable to 48102 to indicate specific circumstances, such as increased procedural services (22) or discontinued procedure (53). Refer to current CPT guidelines.

Medical necessity for 48102 is established when a biopsy is required to evaluate a suspicious pancreatic lesion, rule out malignancy, or diagnose a pancreatic condition.

The physician preps and anesthetizes the patient, identifies the lesion (usually with radiologic guidance), inserts a needle through the skin into the pancreas, obtains tissue samples, and ensures hemostasis.

IMPORTANT:For open biopsy of the pancreas, see 48100. For radiological supervision and interpretation, see 76942, 77002, 77012, 77021. For fine needle aspiration biopsy, see 10005-10012. For evaluation of fine needle aspirate, see 88172, 88173.

In simple words: The doctor takes a small tissue sample from your pancreas using a needle inserted through your skin.This is done using imaging guidance to help locate the area of concern. The sample is then sent to a lab for examination.

This code describes a procedure where a needle is inserted through the skin to obtain a tissue sample from the pancreas for pathological analysis.Radiological guidance is typically used to locate the lesion. Multiple samples may be taken. Hemostasis is achieved by applying pressure to the wound.

Example 1: A patient presents with a suspicious pancreatic mass identified on a CT scan. A percutaneous needle biopsy (48102) is performed under ultrasound guidance to obtain tissue for diagnosis., A patient with chronic pancreatitis has a new area of concern identified on MRI. A percutaneous needle biopsy (48102) is performed to evaluate for malignancy., A patient with a known pancreatic cyst requires a biopsy (48102) to determine its nature.

Documentation should include the indication for the biopsy, the method of localization (e.g., ultrasound, CT), the number of samples obtained, and any complications. A pathology report is also required.

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