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2025 CPT code 65780

Ocular surface reconstruction using amniotic membrane transplantation, multiple layers.

Refer to the CPT manual for complete coding guidelines for ophthalmologic procedures.Use of modifiers may be necessary depending on the specifics of the case.

Modifiers 50 (bilateral procedure), 51 (multiple procedures), 52 (reduced services), and others may be applicable depending on the circumstances of the procedure.

Medical necessity for 65780 is established when a patient has significant corneal or conjunctival surface disease that is refractory to other treatments and is causing significant visual impairment or discomfort. The amniotic membrane serves as a biological bandage, promoting healing and reducing inflammation.

The ophthalmologist or a qualified surgeon performs this procedure.Responsibilities include patient preparation, anesthesia administration (if applicable), surgical technique using an operating microscope, and post-operative care.

IMPORTANT:Code 65426 (Excision or transposition of pterygium; with graft) may also describe this procedure, however 65780-65782 were introduced specifically for ocular surface reconstruction utilizing stem cells from donor grafts.For placement of amniotic membrane without reconstruction using no sutures or a single layer suture technique, see 65778, 65779.Do not report 65760-65771 in conjunction with 92025.

In simple words: This eye surgery repairs damaged parts of the eye's surface using tissue from the placenta.The doctor uses a special microscope to clean the damaged area and carefully places several thin layers of the placenta tissue to cover the damage and help it heal.

This procedure involves the surgical reconstruction of the ocular surface using multiple layers of amniotic membrane grafts.The provider begins by preparing the patient and using an eyelid speculum to keep the eye open.Necrotic epithelium of the cornea is debrided using an operating microscope. An amniotic membrane graft is harvested, prepared, and cut to fit the corneal defect. Multiple layers of the graft are then meticulously placed to cover the defect, ensuring the graft does not extend beyond the margins. The graft is subsequently secured.

Example 1: A patient presents with a severe corneal ulcer following a chemical burn.Multiple layers of amniotic membrane are used to reconstruct the damaged corneal surface., A patient with Stevens-Johnson syndrome has extensive damage to the ocular surface.Amniotic membrane transplantation is used to promote healing and restore the integrity of the conjunctiva and cornea., A patient with recurrent corneal erosion undergoes amniotic membrane transplantation to provide a smooth, stable surface and prevent further damage.

Preoperative documentation should include thorough ophthalmologic examination, including visual acuity, slit-lamp biomicroscopy, and corneal topography. Intraoperative documentation should detail the size and location of the defect, the type and amount of amniotic membrane used, and the surgical technique. Postoperative documentation should include visual acuity, slit-lamp examination, and assessment of graft integration.The use of HCPCS code V2790 should be documented for the supply of the donor tissue.

** This code is specifically for ocular surface reconstruction using multiple layers of amniotic membrane.Medicare reimburses more for 65780 than for 65426.The facility should bill HCPCS code V2790 for the amniotic membrane supply.

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