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2025 CPT code 77321

Special teletherapy port plan for particle beams (electrons, protons, neutrons), hemibody, or total body irradiation.

Code 77321 should be billed only once per treatment course, regardless of the number of treatment sessions or the complexity of the dosimetry involved.The plan must be reviewed and approved by the radiation oncologist and physicist.

Modifiers 26 (professional component) and TC (technical component) may apply depending on who is billing the service.Refer to payer specific guidelines for modifier application.

Medical necessity is established when the complexity of the case requires a specialized plan due to the use of particle beams, hemibody, or total body irradiation, or when the treatment plan cannot be adequately addressed using standard teletherapy isodose plans (CPT codes 77306 or 77307).

Radiation oncologist and medical physicist. The radiation oncologist selects the special beam parameters and is responsible for the overall treatment plan. The medical physicist performs the dosimetry calculations and ensures the accuracy of the plan.

IMPORTANT:May be used in conjunction with other CPT codes for radiation therapy, such as 77306 (simple teletherapy isodose plan) or 77307 (complex teletherapy isodose plan), depending on the overall treatment plan.If intensity modulation is required, CPT 77301 (IMRT plan) might be more appropriate.

In simple words: This code covers the detailed planning needed for special types of radiation therapy, such as using electron, proton, or neutron beams, or treating a large portion of the body.A specialist creates a plan to precisely target the radiation, and this plan is only billed once for the whole treatment.

This CPT code (77321) represents the creation of a special teletherapy port plan that addresses unique beam considerations, such as the use of particle beams (electrons, protons, neutrons), hemibody irradiation, or total body irradiation.The plan involves detailed calculations and considerations for the specific type of radiation, dosage, and treatment area. This service is distinct from simpler teletherapy isodose plans and is billed only once per treatment course, regardless of the number of treatment sessions.The plan must be reviewed and signed by both the radiation oncologist and medical physicist.

Example 1: A patient with extensive melanoma requiring total skin electron beam radiation therapy. Code 77321 would be used to bill for the specialized plan to deliver uniform radiation dose to the entire skin surface., A patient with a large, deep-seated tumor requiring proton beam therapy. The complex treatment plan involving proton beam calculations and dosimetry would be billed using 77321., A patient with a large tumor requiring hemibody irradiation using photon beams. The plan, accounting for the treatment's unique aspects, would be coded as 77321.

Detailed documentation of the patient's diagnosis, tumor location and size, treatment goals, the type of particle beam used (electrons, protons, neutrons), the treatment area (hemibody or total body),dosage calculations, and the plan's approval by both the radiation oncologist and medical physicist.

** This code is specifically for the planning phase of special teletherapy treatments.Separate codes exist for the actual delivery of radiation therapy.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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