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BETA v.3.0

2025 CPT code 80143

Acetaminophen (For definitive drug testing for acetaminophen, see 80329, 80330, 80331)

Modifiers may be applicable, for example, modifier 91 is used for repeat laboratory tests.

Medical necessity is established by the clinical indication for the test, such as suspected overdose, therapeutic monitoring in chronic use, or liver disease.

The laboratory analyst performs the technical aspects of the test. The collecting provider may obtain the specimen.

IMPORTANT:For definitive drug testing for acetaminophen, see 80329, 80330, 80331. Alternate billing code G0480 may be used.

In simple words: This test measures the amount of Tylenol (acetaminophen) in your blood. It's used to make sure you have the right amount for pain or fever control, and to check for overdose.

This test quantifies the level of acetaminophen in a patient's serum or plasma. Acetaminophen is a common over-the-counter analgesic and antipyretic. This test is used to monitor therapeutic levels and to assess potential toxicity in overdose situations.

Example 1: A patient presents to the emergency department with a suspected acetaminophen overdose. An acetaminophen level is ordered (CPT 80143) to assess the severity of the overdose and guide treatment decisions., A patient with chronic pain is prescribed acetaminophen for long-term use. Regular acetaminophen levels (CPT 80143) are monitored to ensure therapeutic levels are maintained and to avoid potential toxicity., A patient with liver disease is taking acetaminophen. Close monitoring of acetaminophen levels (CPT 80143) is required to minimize the risk of liver damage due to drug accumulation.

Documentation should include the reason for the test (e.g., therapeutic monitoring, overdose assessment), time of specimen collection, and any relevant clinical information related to acetaminophen use.

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