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2025 CPT code 80335

Analysis of one or two tricyclic and other cyclical antidepressants in a patient specimen.

This code is specific for the analysis of one or two tricyclic and other cyclical antidepressants. If three to five antidepressants are analyzed, use code 80336. If six or more are analyzed, use 80337. Each code is reported per date of service, even if multiple specimen types are tested. Modifier 59 may be used to indicate testing on different specimen types on the same date of service.

Modifiers may be applicable depending on the specific circumstances of the test. For instance, modifier 90 is used if the test is performed by an outside laboratory, modifier 91 indicates a repeat test, and modifier 59 may be necessary when distinct procedures are performed on the same date of service.

Medical necessity for this test must be established based on the patient's clinical presentation and the intended use of the test results. Justification may include overdose assessment, therapeutic drug monitoring, or evaluation of medication compliance. Documentation should clearly indicate the medical reason for the test.

In simple words: This test measures the amount or checks for the presence of one or two types of antidepressant medications in a sample like blood or urine.

This code represents the quantitative or qualitative analysis of one or two tricyclic and other cyclical antidepressants in a patient specimen such as serum, plasma, or urine. The test may be performed using methods like high-performance liquid chromatography (HPLC) to measure the precise amount or detect the presence of the antidepressants.

Example 1: A patient presents with symptoms of an overdose. This test is ordered to determine the presence and levels of specific tricyclic antidepressants in their system., A patient is on a prescribed regimen of antidepressants. This test is used to monitor the therapeutic levels of the medication in their blood to ensure efficacy and prevent toxicity., A patient is suspected of non-compliance with their prescribed antidepressant medication. This test is ordered to confirm the presence or absence of the drug in their system.

The documentation should include the reason for testing, the specific antidepressants being analyzed, the specimen type, and the date and time of collection. Any relevant clinical findings and the ordering physician's information should also be documented.

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