2025 CPT code 81410
(Active) Effective Date: N/A Pathology and Laboratory Procedures > Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Feed
Genomic sequence analysis panel for aortic dysfunction or dilation, including at least 9 genes (FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, MYLK).
Modifiers may be applicable. Modifier 59 may be used to indicate a distinct procedural service. Modifier 91 is used for repeat laboratory tests.
Medical necessity is established by the presence of signs, symptoms, or family history suggestive of aortic dysfunction or dilation. The test should be ordered to confirm a suspected diagnosis, assess risk, or guide treatment decisions.
The laboratory professional performs the genomic sequence analysis on a patient specimen using NGS technology. They analyze the gene sequences, compare them to a reference genome, and interpret the findings.
In simple words: This test analyzes multiple genes related to problems with the aorta, the main artery from the heart. It helps doctors diagnose conditions that can weaken the aorta and cause it to enlarge or tear. The test uses a patient's blood sample and advanced technology to look for changes in the genes.
This genomic sequencing procedure (GSP) analyzes at least nine genes associated with aortic dysfunction or dilation, including FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK. It aids in diagnosing conditions like Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome type IV, and arterial tortuosity syndrome. The test uses massively parallel sequencing (MPS), often next-generation sequencing (NGS), to analyze DNA from a patient specimen (e.g., blood). The resulting sequence is compared to a reference genome to identify variations.
Example 1: A patient presents with symptoms suggestive of Marfan syndrome, such as tall stature, long limbs, and heart problems. 81410 is ordered to evaluate for genetic variations associated with the condition., A young patient experiences an aortic dissection. 81410 is used to assess for underlying genetic disorders that may have contributed to the event., A pregnant woman with a family history of Loeys-Dietz syndrome undergoes genetic testing using 81410 to determine her risk of vascular complications during pregnancy.
Documentation should include the patient's medical history, family history of related conditions, clinical findings, reason for testing, and the specific genes analyzed.
- Specialties:Clinical Genetics, Cardiology, Vascular Surgery, Maternal-Fetal Medicine
- Place of Service:Independent Laboratory, Hospital Outpatient, Outpatient Clinic