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2025 CPT code 82013

Quantitative measurement of acetylcholinesterase in a sample (serum, plasma, RBCs, or amniotic fluid).

Refer to CPT guidelines for laboratory and pathology codes.When multiple specimens or different times are used, each is reported separately. For organ or disease oriented panels, see codes 80048-80076. If calculated analyte determination requires values from other requested and nonrequested laboratory analyses, the requested analyte codes should be reported.

Modifiers 90 (reference lab) and 91 (repeat test) may be applicable depending on the circumstances.

Medical necessity is established based on the clinical presentation suggesting potential anemia, insecticide exposure, or the need for fetal assessment. The ordering physician must document the clinical indication for the test.

Laboratory personnel perform the quantitative measurement using colorimetric or spectrophotometric instruments.

IMPORTANT:For true cholinesterase or RBC cholinesterase, see 82482.

In simple words: This lab test measures the amount of acetylcholinesterase, an enzyme that helps break down a chemical messenger in the body.The test is done on a blood or fluid sample and helps diagnose certain types of anemia or exposure to harmful chemicals.

This CPT code, 82013, represents the quantitative measurement of acetylcholinesterase (AChE), also known as acetylhydrolase, an enzyme responsible for hydrolyzing the neurotransmitter acetylcholine.The analysis is performed using colorimetric or spectrophotometric methods on a sample, typically serum or plasma, but may also include red blood cells or amniotic fluid depending on the clinical indication. Results are reported quantitatively unless otherwise specified.The test aids in diagnosing conditions such as anemia (spherocytosis, thalassemias), and detecting exposure to insecticides.

Example 1: A patient presents with symptoms suggestive of anemia.A complete blood count (CBC) is ordered, and the physician also requests an acetylcholinesterase level to aid in the differential diagnosis of hereditary spherocytosis., A patient is admitted to the emergency department after suspected exposure to organophosphate insecticides.An acetylcholinesterase level is ordered to assess the severity of the poisoning., A pregnant woman is undergoing prenatal testing.Acetylcholinesterase levels are measured in amniotic fluid as part of a comprehensive fetal assessment.

Physician order specifying the test, patient demographics, sample collection date and time, sample source (serum, plasma, RBCs, amniotic fluid), and the results of the acetylcholinesterase measurement.

** The common abbreviation for acetylcholinesterase is AChE.This test is distinct from the test for true cholinesterase (82482).

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