2025 CPT code 82105
(Active) Effective Date: N/A Revision Date: N/A Laboratory - Chemistry Procedures Pathology and Laboratory Procedures Feed
Quantitative measurement of alpha-fetoprotein (AFP) in serum.
Modifiers 90 (Reference laboratory) and 91 (Repeat test) may apply depending on the circumstances.Other modifiers might be necessary based on individual payer rules.
Medical necessity for AFP testing is established based on clinical indications such as prenatal screening, evaluation of liver disease, or monitoring of certain cancers.The ordering physician must document the clinical rationale for ordering the test.
A laboratory analyst performs the test using an immunoassay method. The ordering physician interprets the results in the context of the patient's clinical presentation.
In simple words: The lab test measures the amount of alpha-fetoprotein (AFP) in a blood sample. AFP is a protein; high levels may suggest a problem with the liver or certain cancers.
This CPT code encompasses the quantitative determination of alpha-fetoprotein (AFP) levels in a serum specimen using an immunoassay method.The procedure involves an antigen-antibody reaction to quantify the amount of AFP present.AFP is a glycoprotein produced during early fetal development; elevated levels in adults may indicate certain types of tumors or liver disease.
Example 1: A pregnant woman undergoes AFP testing as part of prenatal screening for neural tube defects., A patient presents with symptoms suggestive of liver cancer, and AFP levels are measured to aid in diagnosis., A patient with a history of testicular cancer has elevated AFP levels monitored to assess treatment response.
* Patient demographics and relevant medical history.* Physician's order specifying the test.* Specimen collection details (date, time, source).* Laboratory report with quantitative AFP results and units.
** The result is typically reported as a numerical value (e.g., ng/mL).Interpreting AFP results requires clinical correlation and should be done by a qualified healthcare professional.
- Revenue Code: T1H (LAB TESTS - OTHER)
- Payment Status: Active
- Specialties:Obstetrics and Gynecology, Oncology, Gastroenterology, Hepatology
- Place of Service:Office, Hospital (inpatient and outpatient), Laboratory