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BETA v.3.0

2025 CPT code 82163

Angiotensin II

The material for examination can be from any source unless specified. If the analyte is measured in multiple specimens, it's reported separately for each. The examination is quantitative unless specified otherwise. An analyte performed to compensate for variations in urine concentration is reported with the appropriate code for both analytes.

Modifiers such as 90 (Reference [Outside] Laboratory), 91 (Repeat Clinical Diagnostic Laboratory Test), and 99 (Multiple Modifiers) may be applicable based on the specific circumstances.

Medical necessity for angiotensin II testing should be established based on the patient's clinical presentation, such as suspected renovascular hypertension, primary aldosteronism, or other conditions affecting the renin-angiotensin system. Supporting documentation, such as blood pressure readings and other relevant laboratory results, can be used to justify the medical necessity.

The laboratory analyst is responsible for quantitatively measuring the angiotensin II levels in a patient's serum or plasma sample. This typically involves techniques like radioimmunoassay.

In simple words: This test measures the amount of angiotensin II in your blood. Angiotensin II is a hormone that helps control blood pressure.

The lab analyst measures the level of angiotensin II in serum or plasma. The analyte is a natural hormone in the body that affects blood pressure. Angiotensin II acts on blood vessels by constricting them which causes an increase in blood pressure. The lab analyst quantitatively measures the level of the cardiovascular hormone angiotensin II on a blood plasma or serum sample. Methodology is usually by radioimmunoassay, which is a technique that uses a gamma–radioactive tagged isotope that allows a precise measurement using a gamma counter.

Example 1: A patient with suspected hypertension has their angiotensin II levels measured to assess the role of the renin-angiotensin system in their elevated blood pressure., A patient with chronic kidney disease is monitored for angiotensin II levels to manage their condition and adjust medication as needed., A patient on angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) has their angiotensin II levels checked to evaluate the effectiveness of the therapy.

The documentation should include the patient's medical history, the reason for the test, the date and time of sample collection, and the ordering physician's information.

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