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2025 CPT code 82530

Laboratory test to measure the amount of free cortisol in a patient specimen.

Use 82530 when the lab analyst tests the specimen specifically for free cortisol. For total cortisol testing, use code 82533. Specimen collection codes (e.g., 36415 for venipuncture) may be billed separately by some payers.

Modifiers may be applicable in certain circumstances (e.g., 91 for repeat testing). Check payer guidelines for specific modifier requirements.

Medical necessity for this test is established by the presence of signs, symptoms, or conditions that suggest an abnormality in cortisol production, such as suspected Cushing's syndrome, Addison's disease, or adrenal tumors. The test helps to confirm or rule out these diagnoses and guide treatment decisions.

The lab analyst performs the test to measure the amount of free cortisol in a patient specimen. They may use various methodologies such as liquid chromatography tandem mass spectrometry (LC MS).

In simple words: This test measures the level of active cortisol in your blood or urine. Cortisol is a hormone released when you're stressed. This test helps doctors figure out if your body is making the right amount of cortisol.

This test measures the level of unbound cortisol in a patient specimen, typically blood, using methods like liquid chromatography tandem mass spectrometry (LC MS). It's used to diagnose conditions related to abnormal cortisol levels, such as Cushing's syndrome or Addison's disease.

Example 1: A patient presents with symptoms suggestive of Cushing's syndrome (e.g., weight gain, high blood pressure, fatigue). A free cortisol test is ordered to assess if cortisol levels are elevated., A patient experiences symptoms of Addison's disease (e.g., weakness, low blood pressure, darkening of the skin). A free cortisol test is ordered to check for low cortisol levels., A patient with a suspected adrenal tumor undergoes a free cortisol test to evaluate adrenal gland function and assess hormone production.

The documentation should include the reason for the test, the specimen source (e.g., blood, urine), and the date and time of collection. Any relevant clinical findings related to adrenal gland function should also be documented.

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