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2025 CPT code 82784

This code reports the quantitative measurement of a specific gamma globulin (IgA, IgD, IgG, or IgM) in a patient specimen.

Follow CPT guidelines for laboratory reporting, specifically for multiple analyte tests from different sources and specimens. Report each immunoglobulin separately.

Modifiers may be applicable depending on the place of service, the type of laboratory, and whether the test is performed in a physician's office or a reference laboratory. Refer to the CPT codebook and payer-specific guidelines for applicable modifiers.

Medical necessity for this test is established when the ordering physician has clinical indications, such as suspected immunodeficiency, autoimmune disease, or monitoring of response to treatment.The specific immunoglobulin(s) tested should align with the clinical suspicion.

The clinical responsibility for this test lies primarily with the clinical laboratory personnel who perform the technical analysis and report the results. The ordering physician is responsible for interpreting the results in the context of the patient’s clinical presentation and ordering further tests as needed.

IMPORTANT:No alternate codes explicitly provided in source data.Additional codes might be necessary to report related tests, such as specimen collection (e.g., 36415).

In simple words: This lab test measures the amount of a specific type of antibody (immunoglobulin) in your blood or other body fluid.There are different types of immunoglobulins, each playing a role in fighting off infections. This test helps doctors understand your immune system’s health.

CPT code 82784 represents the quantitative determination of a single specified gamma globulin (immunoglobulin) in a patient sample.The analyte can be Immunoglobulin A (IgA), Immunoglobulin D (IgD), Immunoglobulin G (IgG), or Immunoglobulin M (IgM). The specimen source may vary (serum, plasma, cerebrospinal fluid, etc.), with each source and specimen reported separately if multiple are tested.The test is quantitative unless otherwise specified.The clinical responsibility lies with the laboratory analyst who performs the technical aspects of the test, commonly using nephelometry.Results are reported separately for each immunoglobulin tested.This test helps in diagnosing various conditions related to the immune system.

Example 1: A patient presents with recurrent respiratory infections.The physician orders serum IgA, IgG, and IgM levels to assess the patient's humoral immune response and evaluate for potential immunodeficiency., A patient with suspected autoimmune disease undergoes testing for serum IgA, IgG, and IgM. Elevated levels of specific immunoglobulins may support the diagnosis., A patient with a history of recurrent bacterial infections has serum IgG levels measured to assess their response to antibiotic treatment and to detect potential antibody deficiencies.

Physician's order specifying the immunoglobulin(s) to be tested. Patient demographics and identifiers.Specimen collection date, time, and method. Laboratory report indicating the quantitative results for each immunoglobulin tested, along with reference ranges.Any relevant clinical information provided by the ordering physician or obtained during specimen collection.

** Always cross-reference with current CPT guidelines and payer-specific requirements for accurate coding and reimbursement.The choice of specific immunoglobulin(s) is dependent on the clinical scenario. Multiple specimens (e.g., serum, plasma, CSF) from different sources or at different times must be reported separately.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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