2025 CPT code 83529
(Active) Effective Date: N/A Pathology and Laboratory - Chemistry Procedures Pathology and Laboratory Feed
This code represents a quantitative measurement of Interleukin-6 (IL-6) in a specimen such as serum or plasma, often using immunoassay methods.
Modifiers may be applicable to code 83529. Modifier 90 indicates that the test was performed by an outside laboratory. Modifier 91 is used for repeat laboratory tests on the same day. Modifier 99 indicates the use of multiple modifiers.
Medical necessity for 83529 must be supported by documentation of signs, symptoms, or conditions where elevated IL-6 levels are clinically relevant, such as infections, autoimmune diseases, cardiovascular disease, or certain cancers.The test should be ordered when the results will directly influence patient management decisions.
The laboratory analyst performs the assay of Interleukin-6 (IL-6), typically using methods like electrochemiluminescence immunoassay (ECLIA) on specimens like serum or plasma. This involves mixing diluted specimens with IL-6-specific antibodies, conjugating an electrochemiluminescent label to any bound antibody/IL-6 complex, and measuring emitted light intensity to correlate with the IL-6 level. The ordering physician uses the results to evaluate inflammation levels and guide treatment decisions.
In simple words: This test measures the amount of interleukin-6 (IL-6) in your blood. IL-6 is a protein that plays a role in your body's immune and inflammatory responses.High levels of IL-6 can be seen in several conditions, including infections, heart disease, autoimmune diseases, and certain cancers. The test helps doctors understand the level of inflammation in your body.
Assay of Interleukin-6 (IL-6). This test measures the level of interleukin-6 (IL-6) in a specimen, typically serum or plasma. IL-6 is a cytokine involved in immune response and inflammation, and its levels can be elevated in various conditions like infections, cardiovascular disease, autoimmune disorders, and some cancers. The test is typically performed using immunoassay methods like electrochemiluminescence immunoassay (ECLIA).
Example 1: A patient presents with symptoms of rheumatoid arthritis, including joint pain, stiffness, and swelling. The physician orders an IL-6 test (83529) to assess the level of inflammation and guide treatment decisions, such as considering tocilizumab if IL-6 levels are significantly elevated., A patient hospitalized with COVID-19 develops severe respiratory distress. The physician orders an IL-6 test to evaluate the severity of inflammation and determine the potential need for ventilator support. Elevated IL-6 levels may indicate a higher risk of complications and the need for aggressive treatment., A patient with suspected cardiovascular disease undergoes an IL-6 test as part of a comprehensive inflammatory marker panel. The IL-6 result, along with other markers, helps assess the patient's risk of cardiovascular events and guides treatment strategies for managing inflammation.
Proper documentation for 83529 should include the reason for the test (e.g., signs/symptoms of inflammation, suspected condition), the source of the specimen (e.g., serum, plasma), the date and time of collection, and the ordering physician's information. Any relevant clinical findings related to inflammation should also be documented.
- Revenue Code: T1H - LAB TESTS - OTHER (NON-MEDICARE FEE SCHEDULE)
- Payment Status: Active
- Specialties:Rheumatology, Infectious Disease, Cardiology, Oncology, Internal Medicine, Immunology
- Place of Service:Independent Laboratory, Outpatient Hospital, Inpatient Hospital, Office