2025 CPT code 84080
(Active) Effective Date: N/A Pathology and Laboratory - Chemistry Procedures Feed
Alkaline phosphatase isoenzymes test.
Modifiers 90 (Reference Lab), 91 (Repeat Test) are applicable.
Medically necessary when an initial ALP test reveals elevated levels, and further investigation is needed to pinpoint the source and guide treatment.
Ordered when a routine alkaline phosphatase test is abnormal. Helps determine the cause of the elevated ALP, differentiating between liver, bone, or other sources.
In simple words: This test helps determine where in your body elevated alkaline phosphatase levels are originating from, such as liver or bone.
This test helps differentiate between the different forms of alkaline phosphatase (ALP), an enzyme found in several tissues, including liver, bone, and placenta. When a total ALP test (84075) shows elevated levels, this test identifies the source by quantifying specific isoenzymes.
Example 1: A patient with elevated ALP levels and symptoms suggesting liver disease. This test can confirm if the liver is the source., A patient with bone pain and elevated ALP. This test can help diagnose Paget's disease or other bone conditions., During pregnancy, elevated ALP levels can be normal. This test can distinguish between placental and other isoenzymes to rule out other causes.
Requires documentation of the initial ALP test result and the reason for ordering the isoenzyme test, along with relevant clinical findings.
- Revenue Code: T1H
- Payment Status: Active
- Specialties:Pathology, Internal Medicine, Family Medicine, Oncology, Obstetrics/Gynecology, Orthopedics
- Place of Service:Independent Laboratory, Outpatient Hospital