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2025 CPT code 84270

This code represents a laboratory test to measure sex hormone-binding globulin (SHBG) levels in a blood sample.

Follow CPT guidelines for laboratory reporting, including appropriate documentation of specimen source, quantitative measurements, and reporting of multiple specimens.

Modifiers may apply, such as modifier 90 (Reference (Outside) Laboratory) if the test is performed by an outside lab.Consult payer-specific guidelines.

Medical necessity for this test is established when a physician orders it to investigate hormone imbalances, evaluate for endocrine disorders (such as hypogonadism or PCOS), or assess testosterone status in patients exhibiting related symptoms.This often requires correlation with clinical presentation and other relevant laboratory findings.

The clinical responsibility lies with the laboratory personnel who perform the technical aspects of the SHBG blood test, including specimen processing, assay execution, and result reporting.

IMPORTANT Clinicians may order codes 84402 (Testosterone; free) or 84403 (Testosterone; total) instead of this code.The specimen collection may be billed separately using a code such as 36415 (Collection of venous blood by venipuncture).

In simple words: This blood test measures the level of SHBG, a protein that carries sex hormones in your blood.The test helps doctors understand how much testosterone is available for your body to use. This can be helpful in diagnosing conditions related to hormone imbalances.

This CPT code, 84270, encompasses the analytical procedure for determining the concentration of sex hormone-binding globulin (SHBG) in a patient's blood sample.The test involves a quantitative measurement of SHBG, a protein primarily synthesized in the liver that binds to sex hormones such as testosterone, estradiol, and dihydrotestosterone, influencing their bioavailability. The methodology may utilize immunoassay techniques. The results provide insights into the balance of sex hormones and their activity within the body. This test is often used in conjunction with other hormone assays to assess various endocrine conditions.

Example 1: A 35-year-old male patient presents with symptoms of decreased libido and erectile dysfunction.The physician orders this test along with a total testosterone level to evaluate for hypogonadism. Low SHBG levels in the context of low total testosterone would support this diagnosis., A 28-year-old female patient presents with hirsutism and irregular menstrual cycles. The physician orders this test, along with free testosterone and other hormone panels, to investigate potential polycystic ovarian syndrome (PCOS). Elevated SHBG with elevated free testosterone might point towards PCOS., A 60-year-old male patient with a history of type 2 diabetes mellitus presents for a routine check-up. His physician orders this test to assess his hormone levels, particularly testosterone, and check for potential androgen deficiency.

* Patient demographics and relevant medical history.* Physician's order specifying the test.* Details on specimen collection (e.g., date, time, method).* Complete laboratory results, including the SHBG level and reference range.* Any relevant notes or interpretations by the laboratory.

** Interpretation of SHBG levels requires correlation with clinical presentation and other hormone measurements (e.g., total and free testosterone).SHBG levels are influenced by various factors, including age, sex, obesity, liver disease, and thyroid function.

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