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2025 CPT code 84490

Trypsin; feces, quantitative, 24-hour collection.

Medical necessity for this test must be established. Documentation supporting the clinical indication for the test should be provided (e.g., symptoms suggestive of pancreatic insufficiency, such as abdominal pain, weight loss, fatty stools, failure to thrive in infants).

In simple words: This test measures the trypsin enzyme in your poop collected over a day. Trypsin is important for digesting protein. Low levels could mean your pancreas isn't working well.

This test measures the amount of trypsin in a 24-hour stool sample. It is used to evaluate pancreatic function. Trypsin is an enzyme produced by the pancreas that helps digest proteins. Low levels of trypsin in stool may indicate pancreatic insufficiency.

Example 1: A 6-month-old infant has persistent diarrhea, foul-smelling, greasy stools, and is not gaining weight. The pediatrician orders a 24-hour stool collection for trypsin analysis to evaluate for cystic fibrosis., A 45-year-old adult with a history of chronic pancreatitis experiences abdominal pain, weight loss, and oily stools. A 24-hour stool collection for trypsin is ordered to assess pancreatic function., A 2-year-old child has recurrent respiratory infections and failure to thrive. A trypsin test on a 24-hour stool sample is performed to screen for cystic fibrosis.

A 24-hour stool collection is required. The total volume collected should be recorded. Ensure the specimen is free of urine and toilet paper. The specimen should be refrigerated or kept on ice during the collection period. Document any medications the patient is taking, as some may interfere with test results.

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