In simple words: This test measures the total amount of protein S in your blood. Protein S helps prevent blood clots. This test is usually done after another test for "free protein S" shows unusual results. It helps doctors understand if problems with protein S are inherited or caused by other factors like liver disease or certain medications.

This code represents a laboratory test to evaluate the total protein S level in a patient's plasma. Protein S is a vitamin K-dependent anticoagulant protein synthesized in the liver. It acts as a cofactor to activated protein C. This test measures both the bound and unbound (free) forms of protein S in the plasma. This test is typically ordered as a follow-up when free protein S levels (CPT code 85306) are abnormal. It helps to differentiate between congenital and acquired protein S deficiencies, which can be associated with venous or arterial thrombosis, and recurrent pregnancy loss. Acquired deficiencies can be linked to conditions such as liver disease, vitamin K deficiency, or oral anticoagulant therapy.

Example 1: A patient with a history of recurrent deep vein thrombosis has an abnormal free protein S test. The total protein S test is ordered to help determine if the deficiency is congenital or acquired., A woman experiencing recurrent miscarriages undergoes thrombophilia screening, which includes total protein S testing., A patient with known liver disease has their total protein S levels monitored to assess their coagulation status.

Documentation should include the reason for the test (e.g., personal or family history of thrombosis, recurrent miscarriage), relevant medical history, and current medications. The type of assay performed (total protein S) should be clearly specified.