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BETA v.3.0

2025 CPT code 86367

Stem cells (ie, CD34), total count.

For flow cytometric immunophenotyping for the assessment of potential hematolymphoid neoplasia, see 88184-88189. Do not report 86367 for assessment of potential hematolymphoid neoplasia.

Modifiers may be applicable to 86367 in specific circumstances, such as when the test is performed as a distinct procedural service (modifier 59).

Medical necessity for 86367 is established when the CD34 stem cell count is required for diagnosis, treatment planning, or monitoring of conditions related to hematopoietic stem cells, such as bone marrow transplantation or alveolar soft part sarcoma.

The lab analyst performs the technical steps to test the patient’s blood to identify the total number of CD34, or stem cells, in the patient blood sample. The analyst uses an immunomagnetic or immunofluorescent method to perform this test. The test may include various steps such as isolating the cells first, and using antibodies to quantify and purify the hematopoietic progenitor stem cells.

In simple words: This test counts the number of CD34 stem cells in your blood. It's used to prepare for bone marrow transplants and sometimes for research.

The lab analyst performs a test to count the total number of CD34, or stem cells in a patient specimen, typically a blood specimen. The analyst uses an immunomagnetic or immunofluorescent method to perform this test. The test may include various steps such as isolating the cells first, and using antibodies to quantify and purify the hematopoietic progenitor stem cells. Although not limited to testing for specific conditions, clinicians may order this test to quantify and purify the hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. CD34 is also found in the alveolar soft part of a sarcoma.

Example 1: A patient is being evaluated for a bone marrow transplant. The physician orders a CD34 stem cell count (86367) to determine the number of stem cells available for transplantation., A researcher is conducting a study on hematopoietic stem cell transplantation and requires an accurate count of stem cells for analysis, thus 86367 is ordered., A patient presents with suspected alveolar soft part sarcoma.A CD34 stem cell count (86367) may be performed to aid in diagnosis and staging, along with other tests.

Documentation should include the reason for the test, the method used (immunomagnetic or immunofluorescent), and the results, including the total number of CD34+ cells.

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