In simple words: This test looks for special proteins called antibodies in your blood that may be attacking your own body tissues, specifically those found in your liver, kidney, or thyroid. These "microsomal antibodies" can cause certain types of hepatitis or thyroid disease. The test helps doctors figure out if you have these diseases and how they are progressing.

This code represents the qualitative or semiquantitative analysis of microsomal antibodies in a patient sample, typically serum.These antibodies, such as liver-kidney microsomal antibody (LKM-1) and thyroid peroxidase antibody (TPO), are autoantibodies associated with certain autoimmune diseases like autoimmune hepatitis type 2 and autoimmune thyroid disease. The test helps in diagnosing and monitoring these conditions.Methodologies may include enzyme-linked immunosorbent assays (ELISA) or electrochemiluminescence immunoassays (ECLIA).

Example 1: A pediatrician suspects autoimmune hepatitis type 2 in a young child presenting with jaundice, fatigue, and elevated liver enzymes.The pediatrician orders a microsomal antibody test (CPT 86376) to check for the presence of LKM-1 antibodies., An endocrinologist is evaluating a patient with symptoms suggestive of Hashimoto's thyroiditis, such as fatigue, weight gain, and dry skin. They order a microsomal antibody test (CPT 86376) to detect TPO antibodies., A patient with a known diagnosis of autoimmune hepatitis is undergoing regular monitoring to assess disease activity.Their physician orders a microsomal antibody test (CPT 86376) to track LKM-1 antibody levels.

Documentation should include the reason for the test, the patient's relevant medical history, and the interpretation of the test results in the context of the patient's clinical presentation.