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2025 CPT code 86780

Qualitative or semiquantitative immunoassay for Treponema pallidum antibodies.

Follow all relevant CPT coding guidelines and payer-specific instructions when billing this procedure code.Note that this code is specifically for antibody detection, not antigen detection.

Modifiers may be applicable depending on the circumstances of service. Consult the CPT manual and payer guidelines for appropriate modifier usage.

Medical necessity for this test is established when there is clinical suspicion of syphilis based on the patient's symptoms, risk factors (e.g., recent sexual contact with an infected individual, history of syphilis), or as part of routine screening (e.g., prenatal care).The test helps in early diagnosis and treatment of syphilis, preventing complications.

The clinical responsibility lies with the laboratory analyst who performs the technical aspects of the immunoassay, including sample preparation, reagent mixing, incubation, and result interpretation. The ordering physician is responsible for medical decision-making based on the results.

IMPORTANT:For syphilis testing using non-treponemal antibody analysis, see codes 86592 and 86593. For antigen detection, use code 87285.

In simple words: This lab test checks a blood sample for antibodies to the bacteria that cause syphilis. The test shows if you have or had syphilis.

This CPT code, 86780, represents the performance of a qualitative or semiquantitative immunoassay to detect antibodies against Treponema pallidum in a patient's serum.The procedure involves techniques such as particle agglutination to identify the presence and, potentially, the concentration of these antibodies, which are indicative of syphilis infection. The results are interpreted as positive, negative, or a semiquantitative value.This code is specifically for antibody detection; for antigen detection, use code 87285.

Example 1: A patient presents with symptoms suggestive of secondary syphilis (rash, fever). The physician orders this test to confirm the diagnosis., A pregnant woman undergoes routine prenatal screening, which includes this test to detect syphilis infection and prevent potential transmission to the fetus., A patient with a history of syphilis is monitored for recurrent infection, and this test is performed to assess the antibody levels.

** The test results should be interpreted in conjunction with the patient's clinical history and other relevant laboratory findings.False positive results can occur, necessitating confirmatory testing.

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