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BETA v.3.0

2025 CPT code 86800

Thyroglobulin antibody. (For thyroglobulin, use 84432)

Immunology analytes/procedures not specified in 86015-86835 and not in the Chemistry subsection (82009-84830) may be reported using the unlisted immunology procedure code 86849.

Modifiers 90 (Reference [Outside] Laboratory), 91 (Repeat Clinical Diagnostic Laboratory Test), and 99 (Multiple Modifiers), along with others, may be applicable.

Medical necessity for 86800 is based upon the evaluation of signs, symptoms, and clinical suspicion for thyroid disease, especially autoimmune thyroiditis such as Hashimoto’s thyroiditis and Graves' disease. It can also be used in monitoring patients with a history of thyroid cancer.

The lab analyst performs the technical steps to test the patient’s sample for antibodies to thyroglobulin using an immunoassay method. Clinicians typically order this test to help diagnose and differentiate autoimmune from other thyroid disorders.

In simple words: This test checks your blood for antibodies against thyroglobulin, a protein made by your thyroid.It helps doctors figure out if you have a thyroid problem, especially an autoimmune thyroid disease like Hashimoto's thyroiditis or Graves' disease.

A lab analyst performs an immunoassay to evaluate the patient’s serum for antibodies to thyroglobulin, a protein produced by the thyroid gland that synthesizes, stores, and releases thyroid hormones. The test may include various steps such as reacting the specimen with test antigens, incubating the mixture, adding an agent to detect the antigen antibody complex, and interpreting the results.

Example 1: A patient presents with fatigue, weight gain, and constipation.A physician orders a thyroglobulin antibody test (86800) to assess for Hashimoto's thyroiditis., A patient with a history of thyroid cancer is being monitored for recurrence. The physician orders a thyroglobulin antibody test along with a thyroglobulin test (84432), as antibodies can interfere with thyroglobulin testing., A patient exhibits symptoms of hyperthyroidism such as weight loss, rapid heartbeat, and anxiety. A thyroglobulin antibody test is ordered, among other tests, to help evaluate for Graves' disease.

Medical record should document the reason for ordering the thyroglobulin antibody test, including relevant signs, symptoms, and/or the diagnosis being considered.

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