2025 CPT code 86833
(Active) Effective Date: N/A Revision Date: N/A Deletion Date: N/A Pathology and Laboratory Procedures - Tissue Typing Immunological Procedures Immunology Procedures Feed
High-definition qualitative HLA Class II antibody identification using solid-phase immunoassay (e.g., microspheres).
Modifiers may apply depending on the circumstances of the test (e.g., modifier 90 for testing performed in an outside lab). Consult CPT guidelines and payer guidelines for appropriate modifier usage.
Medical necessity is established by the physician's order, indicating the patient's clinical status necessitating this test (e.g., pre-transplant evaluation, post-transplant monitoring, evaluation of suspected rejection).The results will help guide the transplant process.Payers may require additional documentation supporting medical necessity.
The clinical responsibility lies with the laboratory analyst who performs the technical aspects of the test, including specimen handling, assay execution, data analysis, and result reporting.
In simple words: This lab test checks a blood sample to identify specific antibodies that might cause problems with organ or bone marrow transplants.It uses a special method to pinpoint exactly which antibodies are present, helping doctors find the best possible match for a transplant.
This CPT code reports a high-definition qualitative test identifying specific antibodies to human leukocyte antigens (HLA) Class II in patient serum.The test utilizes a solid-phase immunoassay, such as microspheres or beads, ELISA, or flow cytometry, with a high-definition method (e.g., one antigen per bead). The lab analyst mixes the patient serum with beads coated with specific HLA Class II antigens. A visible marker (e.g., fluorescent immunoglobulin) indicates antibody-antigen reactions. The analyst then evaluates these reactions using specialized instruments and processes, reporting the specific HLA Class II antibodies present.This test helps determine compatibility for organ or bone marrow transplants, monitoring transplant recipients for antibody development, and assessing the risk of transplant rejection.
Example 1: A patient is awaiting a kidney transplant.This test helps determine the presence and specificity of HLA Class II antibodies in their serum to assess compatibility with potential donors. Results guide selection of a suitable donor based on minimal risk of rejection., A patient received a liver transplant six months ago.This test is used to monitor for the development of de novo donor-specific antibodies. Elevated levels may indicate potential transplant rejection, requiring intervention., A patient with a history of multiple blood transfusions is considering a bone marrow transplant.This high-resolution testing helps to identify specific HLA Class II antibodies that may cause graft versus host disease or rejection.Detailed analysis allows for better donor selection and risk stratification.
Patient demographics, date of test, specimen collection details (including date and time), test results clearly showing specific HLA Class II antibodies identified, and physician's order with appropriate medical necessity.
** This high-definition test provides more precise information compared to other HLA Class II antibody tests.The test may be ordered as a reflex test following a positive result on a less specific screening test. The specificity of this test can help in avoiding unnecessary organ or bone marrow transplant rejections.
- Revenue Code: T1H (LAB TESTS - OTHER (NON-MEDICARE FEE SCHEDULE))
- RVU: Information not provided. RVUs vary based on geographic location, facility type, and payer.
- Global Days: Not applicable. This is a laboratory test, not a surgical procedure.
- Payment Status: Active
- Modifier TC rule: Not applicable. This is a comprehensive laboratory test.
- Fee Schedule: Historical fee schedule data is unavailable.Refer to payer-specific fee schedules and historical data for specific years.
- Specialties:Transplant surgery, immunology, nephrology, hepatology, hematology/oncology
- Place of Service:Office, Hospital (Inpatient/Outpatient), Laboratory