In simple words: This lab test screens for HIV-1 and HIV-2 infection by checking for viral proteins (antigens) and the body's response to the virus (antibodies). The test gives one overall result, not specifying whether it's from the virus or the body's reaction.A positive result needs confirmation before an HIV diagnosis is made.

This CPT code encompasses the qualitative or semiquantitative detection of HIV-1 antigens and antibodies to both HIV-1 and HIV-2 using immunoassay techniques such as enzyme immunoassay (EIA), enzyme-linked immunosorbent assay (ELISA), fluorescence immunoassay (FIA), or immunochemiluminometric assay (IMCA). The test provides a single result, not differentiating between the presence of HIV-1 antigen or HIV-1 and HIV-2 antibodies.It is performed on a primary specimen (e.g., serum) and does not include testing of cultured isolates.

Example 1: A patient presents with symptoms suggestive of HIV infection.The clinician orders an HIV-1/HIV-2 antigen/antibody screen (87389) as an initial screening test. The result is negative, ruling out HIV infection (at this stage)., A patient at high risk for HIV undergoes routine screening. The 87389 test returns a positive result. The physician orders confirmatory tests (e.g., 86701-86703) to verify the presence of HIV antibodies., During prenatal care, the 87389 test is performed as part of routine screening for HIV. The result is negative.The result is documented in the patient's chart.

Patient demographics, date and time of specimen collection, method of specimen collection (e.g., venipuncture, finger stick), specimen type (e.g., serum, plasma), test result, date of testing, physician's order for testing, and any relevant clinical information.

** This test serves as a screening tool, and positive results require confirmatory testing for a definitive diagnosis.The specific immunoassay method used should be documented.Specimen handling and storage guidelines are crucial for test accuracy.