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BETA v.3.0

2025 CPT code 88375

Optical endomicroscopic image(s), interpretation and report, real-time or referred, each endoscopic session.

Refer to CPT guidelines for surgical pathology procedures and endomicroscopy.

Modifiers may be applicable based on specific payer guidelines.

Medical necessity for 88375 is established when endomicroscopy is necessary to evaluate suspicious tissue or lesions during an endoscopic procedure, aiding in diagnosis and guiding treatment decisions.

A qualified provider, typically a pathologist, is responsible for reviewing the endomicroscopic images, providing real-time or deferred interpretation, and generating a report for each endoscopic session.

In simple words: A pathologist examines highly detailed images taken during an endoscopy (internal camera examination).These images, called optical biopsies, help doctors diagnose problems. The pathologist reviews the images and creates a report explaining the findings.

Interpretation and report of real-time or referred optical endomicroscopic images for each endoscopic session.This involves a pathologist providing real-time evaluation in a procedure room or receiving and interpreting images taken by a clinician during an endomicroscopic procedure. The pathologist provides a report for each endoscopic session.

Example 1: A patient undergoes an upper endoscopy for evaluation of Barrett's esophagus. Real-time endomicroscopy is used to assess suspicious areas. The pathologist interprets the images and provides a report to the gastroenterologist., A patient undergoes colonoscopy for screening. Endomicroscopy is used to evaluate a polyp.The endoscopist refers the images to a pathologist for later review and interpretation, who then generates a report., During a bronchoscopy, endomicroscopy helps assess a lung lesion. A pathologist interprets the images remotely and provides a real-time report to the pulmonologist guiding the procedure.

Documentation should include the endoscopic procedure performed, the indication for endomicroscopy, the number of images reviewed, the real-time or referred nature of the interpretation, and a detailed pathology report of the findings.

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