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2025 CPT code 89291

Microtechnique biopsy of oocyte polar bodies or embryo blastomeres for preimplantation genetic diagnosis (PGD); more than 5 embryos.

Refer to the latest CPT and other relevant coding manuals for specific coding guidelines and updates.

Modifiers may be applicable depending on the circumstances of service. Consult the CPT manual for appropriate modifier use.

Medical necessity is established when PGD is deemed clinically appropriate by the physician due to factors such as advanced maternal age, recurrent miscarriages, family history of genetic disorders, or previous failed IVF cycles.Documentation must support the medical necessity.

A laboratory analyst performs the technical aspects of the biopsy.The ordering physician is responsible for medical decision-making based on the results.

IMPORTANT:For 5 or fewer embryos, use CPT code 82920.Code 89291 is solely for the biopsy; it excludes services such as culture or transfer preparation.

In simple words: This lab test checks the health of multiple embryos created during in-vitro fertilization (IVF) before they are implanted. A tiny sample is taken from each embryo to look for genetic problems. This helps ensure a healthy pregnancy.

This CPT code encompasses the microtechnique biopsy of oocyte polar bodies or embryo blastomeres for preimplantation genetic diagnosis (PGD).The procedure involves the aspiration and removal of cells from greater than five embryos to screen for genetic disorders prior to embryo transfer during an IVF cycle. This is a laboratory procedure performed to assess the genetic makeup of the embryos before implantation. The technique uses a microscope to precisely remove the cells for analysis.

Example 1: A couple undergoing IVF for recurrent miscarriage has more than five embryos created.PGD is performed using 89291 to screen for chromosomal abnormalities before embryo transfer., A patient with a family history of a specific genetic disorder opts for PGD using 89291 to identify embryos free from that disorder among a batch of more than five embryos., A couple with advanced maternal age undergoes IVF with more than five embryos generated, and PGD is done using 89291 to select genetically healthy embryos for transfer, improving the chance of a successful pregnancy.

* Patient consent for PGD.* Detailed IVF cycle report.* Embryology lab report including the number of embryos biopsied, the technique used, and the results of the genetic analysis.* Documentation of the genetic disorder(s) screened for.* Results of the genetic testing and physician's interpretation.

** This code is specific to the microtechnique biopsy aspect of PGD and does not encompass other procedures, such as egg retrieval, fertilization, or embryo transfer, which are separately reported. Accurate reporting requires detailed documentation of the procedure and the number of embryos.

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