2025 CPT code 90281
(Active) Effective Date: N/A Revision Date: N/A Medicine - Immune Globulins, Serum or Recombinant Products Medicine Services and Procedures Feed
Intramuscular administration of human immune globulin.
Modifiers may be applicable depending on the circumstances of the service. Consult the CPT codebook for specific modifier guidelines.
Medical necessity for immune globulin administration is determined by the patient's clinical condition, such as primary immunodeficiency disorders, secondary immunodeficiencies (e.g., due to chemotherapy), or exposure to certain infectious diseases.Documentation supporting the medical necessity should include details about the patient's condition, the reason for administering the immune globulin, and the anticipated benefits of the treatment.
The physician or qualified healthcare professional is responsible for selecting the appropriate immune globulin product based on the patient's needs, preparing the injection, inspecting the injection site, administering the injection slowly using an appropriately sized needle, and monitoring the patient for any adverse reactions.
In simple words: This code covers the injection of a medicine called immune globulin into a muscle.Immune globulin helps protect against infections.The cost of the medicine itself is billed separately.
This CPT code, 90281, represents the intramuscular administration of human immune globulin.This includes the preparation and administration of the immunoglobulin product, which can be serum-derived or recombinant.The code does not include the cost of the immunoglobulin product itself; that must be billed separately.Proper documentation should detail the type and amount of immunoglobulin administered, the injection site, and any adverse reactions.
Example 1: A patient with a weakened immune system due to chemotherapy receives an intramuscular injection of immune globulin to prevent infection., A child exposed to measles receives an intramuscular injection of immune globulin for passive immunization., A patient with a known immunodeficiency receives a scheduled intramuscular injection of immune globulin as part of their ongoing treatment.
* Type and amount of immunoglobulin administered.* Injection site.* Date and time of administration.* Patient's diagnosis and medical history.* Any adverse reactions to the injection.* Physician's order.
** The cost of the immune globulin product itself is billed separately.Always verify payer-specific requirements for documentation and billing.
- Revenue Code: P6D (MINOR PROCEDURES - OTHER (NON-MEDICARE FEE SCHEDULE))
- RVU: Information not available in provided text.RVUs vary by payer and location.
- Global Days: Not applicable. This is an injection, not a surgical procedure.
- Payment Status: Active
- Modifier TC rule: Not applicable.This code represents administration, not a technical component.
- Fee Schedule: Information not available in provided text. Fee schedules vary by payer and location.
- Specialties:Infectious Disease, Immunology, Hematology, Oncology
- Place of Service:Office, Inpatient Hospital, Outpatient Hospital, Ambulatory Surgical Center