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2025 HCPCS code A2021

Neomatrix, per square centimeter

Report A2021 for each square centimeter of Neomatrix used. Modifier units should reflect the exact quantity used.

Modifiers such as RT (right side) or LT (left side) may be applicable.

Medical necessity for A2021 must be established by documenting the clinical rationale for its use in wound management, such as the presence of a non-healing ulcer, infected wound, or other clinical conditions requiring advanced wound care.

The provider supplies and may apply the Neomatrix Wound Matrix to a wound (e.g., ulcer, surgical wound, trauma wound) as part of wound care.The code is reported per square centimeter used.

In simple words: This code covers a special wound dressing made from amphibian skin, used to help wounds heal.It's billed for each square centimeter used.

Neomatrix™ Wound Matrix, made from axolotl (amphibian) skin, is used for wound management and is reported per square centimeter.

Example 1: A patient with a diabetic foot ulcer measuring 2cm x 3cm requires application of Neomatrix. The code A2021 is reported six times., A patient with a post-surgical wound infection receives Neomatrix to facilitate healing. The size of the wound and thus the number of units of A2021 reported will depend on the measurements of the wound., A patient with a large burn wound requires extensive wound management, including the use of Neomatrix. The provider applies the material to the affected area and reports A2021 for each square centimeter of the wound covered.

Documentation should include the size of the wound (length x width) to justify the number of units of A2021 billed, the location of the wound, the etiology of the wound, and the medical necessity for the use of Neomatrix.

** HCPCS Level II codes beginning with 'A' represent ambulance and transport services and supplies; medical and surgical supplies; and administrative, miscellaneous, and investigational services.

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