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2025 HCPCS code J2550

Injection, promethazine HCl, up to 50 mg

Use J-codes for drugs that cannot be self-administered, for chemotherapy and immunosuppressive drugs, inhalation solutions, and other miscellaneous drugs. This is a generic drug. This code represents the supply of the drug. Check coding and individual payer guidelines to determine whether you can also report the administration of the drug.

Modifiers may be applicable depending on the specific circumstances of the administration. Refer to payer guidelines and current coding manuals.

Medical necessity for J2550 must be supported by documentation of a qualifying medical condition such as an allergic reaction, nausea and vomiting (especially post-operatively), or other conditions where promethazine is indicated. The documentation should clearly link the administration of the drug to the patient's symptoms and treatment plan.

The provider uses promethazine to alleviate allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. It is also used to treat nausea and vomiting after surgery. The code represents the supply of the drug only, not the administration.

In simple words: This code is for a shot of promethazine, a medicine used to treat allergies. It helps with things like itching and runny nose. This code covers up to 50 mg of the medicine.

Promethazine HCl injection, up to 50 mg. Routes of administration include intravenous, intramuscular, and others. Promethazine is a phenothiazine used to treat allergy symptoms like itching and runny nose. It works by changing the action of chemicals in the brain and has antihistamine properties. This code represents the drug only, not its administration.

Example 1: A patient presents to the emergency department with severe allergic reaction after a bee sting. They are given J2550, promethazine HCl, intravenously to control the allergic symptoms., A patient is receiving post-operative care after a surgical procedure and experiencing nausea and vomiting. They are administered J2550, promethazine HCl, intramuscularly to control the nausea and vomiting. , A patient with a history of seasonal allergies visits their physician with complaints of itching and runny nose. They receive an intramuscular injection of J2550, promethazine HCl, to alleviate their symptoms.

Documentation should include the diagnosis necessitating the use of promethazine HCl, the dosage administered, the route of administration, and the patient's response to the medication. Any related allergy information or post-surgical details are also important to document.

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