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2025 HCPCS code J2791

Injection, Rho(D) immune globulin (human), (Rhophylac), intramuscular or intravenous, 100 IU.

This code represents the drug itself and not the administration. Appropriate administration codes should also be reported if applicable and allowed by payer guidelines.

Medical necessity for J2791 is established when used to suppress Rh isoimmunization in Rh-negative individuals exposed to Rh-positive blood, or for the treatment of ITP in eligible patients, as supported by clinical guidelines and payer policies.

Administering Rho(D) immune globulin (Rhophylac) within 72 hours of exposure to Rh-positive blood for incompatible transfusions or as indicated for Rh isoimmunization suppression and ITP treatment in adults.

IMPORTANT For Rhophylac administered intramuscularly at different dosages, consider J2788 (50 mcg) and J2790 (300 mcg). For other brands or generic Rho(D) immune globulin, refer to other J-codes.

In simple words: Rhophylac is a medicine given as an injection into a muscle or vein. It prevents people with Rh-negative blood from developing a harmful reaction if they are exposed to Rh-positive blood.

This code represents 100 international units (IU) of Rhophylac, a brand of Rho(D) immune globulin (human), administered either intramuscularly or intravenously. It is used to prevent an immune response to Rh-positive blood in patients with Rh-negative blood.

Example 1: An Rh-negative pregnant woman receives Rhophylac during her pregnancy to prevent sensitization to potential Rh-positive fetal blood., An Rh-negative patient receives a transfusion of Rh-positive blood and is administered Rhophylac to prevent the formation of antibodies against the Rh factor., A non-splenectomized adult with chronic Immune Thrombocytopenic Purpura (ITP) who is Rh-positive receives Rhophylac intravenously to increase platelet counts.

Documentation should include the patient's Rh status, the reason for administration (e.g., pregnancy, transfusion, ITP), the dosage administered, the route of administration (IM or IV), and the date and time of administration.

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