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2025 ICD-10-CM code A41.01

Sepsis due to Methicillin susceptible Staphylococcus aureus (MSSA).

Use additional codes to specify any underlying conditions or complications related to the sepsis.

Medical necessity for treatment of MSSA sepsis is established by the presence of clinical indicators of sepsis and confirmation of MSSA infection through laboratory testing.

Clinicians diagnose MSSA sepsis based on patient symptoms (skin infections, fever, low blood pressure, difficulty breathing, altered mental state), history, and physical findings. Laboratory tests, including blood cultures and drug sensitivity testing, confirm the diagnosis and guide treatment.

In simple words: MSSA sepsis is a serious condition where the body overreacts to a staph infection that can be treated with methicillin. It can cause symptoms like fever, low blood pressure, and difficulty breathing.

Sepsis due to Methicillin susceptible Staphylococcus aureus (MSSA) is a potentially life-threatening condition characterized by a systemic inflammatory response to an infection by MSSA bacteria, which are susceptible to methicillin treatment.

Example 1: A patient with a post-surgical wound develops fever, chills, and hypotension. Blood cultures reveal MSSA, indicating sepsis., An individual with a history of intravenous drug use presents with fever, heart murmur, and signs of systemic infection. MSSA is identified as the causative agent of infective endocarditis and subsequent sepsis., A child with a skin infection develops rapid breathing, lethargy, and poor perfusion. MSSA sepsis is diagnosed, requiring prompt antibiotic therapy and supportive care.

Documentation should include signs and symptoms of sepsis, positive MSSA culture results, drug sensitivity testing, and any underlying conditions or procedures that may have contributed to the infection.

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