In simple words: Solitary plasmacytoma is a rare blood cancer where abnormal plasma cells form a single tumor in the bone or soft tissue. Symptoms depend on where the tumor is.

Solitary plasmacytoma is a rare plasma cell cancer characterized by a single localized mass of abnormal plasma cells. It can develop in bone (solitary bone plasmacytoma) or soft tissue (extramedullary plasmacytoma).Symptoms vary depending on the location and size of the tumor and can include pain, fractures, headaches, and compression of the spinal cord or nerve roots.

Example 1: A 50-year-old male presents with persistent back pain. Imaging reveals a solitary lesion in the thoracic vertebrae. Biopsy confirms solitary bone plasmacytoma., A 65-year-old female experiences headaches and dizziness. A skull lesion is found on MRI, and biopsy confirms solitary plasmacytoma., A 55-year-old male presents with nasal obstruction and discharge. A soft tissue mass is found in the nasal cavity, and biopsy confirms extramedullary plasmacytoma.

Documentation should include biopsy results confirming monoclonal plasma cells, imaging studies showing a single localized tumor, and absence of systemic myeloma features. Bone marrow biopsy results and blood tests should also be documented.

** Solitary plasmacytoma can progress to multiple myeloma, requiring ongoing monitoring and follow-up.