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2025 ICD-10-CM code C91.1

Chronic lymphocytic leukemia of B-cell type.

Use additional codes to specify any associated conditions, like anemia or infections.

Medical necessity for treatment is determined by the stage and progression of CLL. Asymptomatic patients may be monitored, while symptomatic or advanced-stage patients may require interventions like chemotherapy or radiation therapy.

Diagnosis involves patient history, physical examination, blood tests (CBC, peripheral blood smear, LDH, liver and kidney function tests, PCR, flow cytometry), bone marrow aspiration/biopsy, and imaging studies (ultrasound). Treatment varies depending on the stage and may include watchful waiting, radiation therapy, or chemotherapy.

In simple words: B-cell chronic lymphocytic leukemia (B-CLL) is a type of blood cancer that mostly affects older adults.It occurs when white blood cells called B-lymphocytes, which are part of the immune system, become abnormal and multiply out of control in the bone marrow. This prevents the body from making enough healthy blood cells.

Chronic lymphocytic leukemia (CLL) of B cell type is a slow-growing leukemia where abnormal B lymphocytes multiply uncontrollably and accumulate in the bone marrow, hindering normal blood cell production. It primarily affects older adults.

Example 1: A 70-year-old patient presents with painless swelling in the neck and underarms, fatigue, and frequent infections. Blood tests and bone marrow biopsy confirm a diagnosis of B-cell CLL., An 80-year-old patient with B-CLL experiences an enlarged spleen. Treatment decisions will be based on the clinical stage of CLL, overall health of patient, and patient preferences., During a routine check-up, blood work reveals an elevated white blood cell count in a 65-year-old individual, leading to further investigations and a diagnosis of early-stage CLL.

Documentation should include complete blood count (CBC) results, bone marrow biopsy findings, imaging reports, and a detailed clinical history outlining the patient's symptoms, such as lymphadenopathy, splenomegaly, fatigue, and infections.

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