2025 ICD-10-CM code C92.A
Acute myeloid leukemia with multilineage dysplasia. This condition often presents with severe cytopenia and arises de novo.
Medical necessity is established by the confirmed diagnosis of acute myeloid leukemia with multilineage dysplasia through bone marrow examination and appropriate blood workup.The medical necessity for specific treatment approaches will depend on individual patient circumstances and disease severity.
Diagnosis involves patient history, physical exam, blood tests (CBC, peripheral smear, blood chemistries, coagulation studies), bone marrow biopsy or aspiration, lumbar puncture, cytologic and microscopic analysis, flow cytometry, PCR, FISH, genetic analysis, and imaging (CT, MRI, PET, ultrasound). Treatment includes chemotherapy, targeted chemotherapy, stem cell transplant, radiation therapy (in specific situations), and surgery (in specific situations).
In simple words: Acute myeloid leukemia with multilineage dysplasia is a type of blood cancer that starts in the bone marrow. It's different from other acute myeloid leukemias because it shows signs of abnormal cell development in multiple blood cell lines. It occurs on its own, not because of prior treatment, and patients often have low blood counts.
Acute myeloid leukemia with multilineage dysplasia is a type of acute myeloid leukemia characterized by myelodysplastic features in at least 50% of the cells of at least two hematopoietic cell lines. It arises de novo and is not a result of treatment.Patients often present with severe cytopenia, a reduction in the number of blood cells. It differs from AML with myelodysplasia-related changes (AML-MRC) as defined by the 2008 WHO classification.
Example 1: A 70-year-old patient presents with fatigue, easy bruising, and recurrent infections. Blood tests reveal pancytopenia. Bone marrow biopsy shows blasts with myelodysplastic features in multiple cell lines, confirming the diagnosis of acute myeloid leukemia with multilineage dysplasia., A patient with a history of myelodysplastic syndrome develops acute myeloid leukemia. However, genetic testing does not reveal any specific abnormalities characteristic of AML with recurrent genetic abnormalities. Morphological review reveals dysplasia in multiple cell lines leading to a diagnosis of acute myeloid leukemia with multilineage dysplasia, distinct from AML-MRC., A 55-year-old patient presents with symptoms suggestive of leukemia.After comprehensive testing, including bone marrow biopsy, flow cytometry and cytogenetic analysis, they are diagnosed with acute myeloid leukemia with multilineage dysplasia, without prior history of MDS or MDS/MPN and without specific recurrent genetic abnormalities characterizing other AML subtypes.
Documentation should include complete blood count (CBC) results showing cytopenia, bone marrow biopsy/aspiration findings confirming the presence of blasts with multilineage dysplasia (at least two cell lines with 50% or more dysplastic cells), and results from relevant genetic testing, flow cytometry and cytogenetic analysis.
- Specialties:Hematology, Oncology
- Place of Service:Inpatient Hospital, Outpatient Hospital, Office