2025 ICD-10-CM code D47.02
Indolent systemic mastocytosis. This condition involves an abnormal accumulation of mast cells in various tissues and organs, leading to a range of symptoms.
Medical necessity for services related to indolent systemic mastocytosis is established by the presence of signs, symptoms, and laboratory findings consistent with the diagnosis. Documentation should support the need for diagnostic testing, treatment, and monitoring of the disease and its potential complications.
Physicians diagnosing and managing indolent systemic mastocytosis have responsibilities encompassing accurate diagnosis, symptom management, and monitoring for disease progression. This involves a thorough evaluation of the patient's medical history, physical examination, and laboratory testing (including blood counts, tryptase levels, and genetic testing). They also educate patients about potential triggers and management strategies. Referral to specialists, such as hematologists or allergists, may be necessary.
In simple words: Indolent systemic mastocytosis is a condition where your body produces too many mast cells, a type of white blood cell involved in allergic reactions.These excess mast cells build up in different parts of your body like your skin, bones, and organs.This build-up can cause a variety of symptoms, such as itchy skin rashes, stomach problems, and bone pain.The term "indolent" means that the disease progresses slowly.
Indolent systemic mastocytosis (ISM) is characterized by the abnormal proliferation and accumulation of mast cells in one or more organ systems, typically the skin, bone marrow, liver, spleen, and gastrointestinal tract. This can lead to a variety of symptoms, including skin rashes, itching, flushing, abdominal pain, nausea, vomiting, diarrhea, bone pain, and fatigue. In some cases, ISM may progress to more aggressive forms of mastocytosis or other hematological disorders.
Example 1: A 45-year-old patient presents with recurrent episodes of flushing, itching, and hives, along with abdominal pain and diarrhea.A bone marrow biopsy reveals an increased number of mast cells, confirming the diagnosis of indolent systemic mastocytosis., A 60-year-old patient experiences unexplained bone pain and fatigue. Blood tests reveal an elevated tryptase level, and a bone marrow biopsy confirms the presence of indolent systemic mastocytosis with associated bone involvement., A 30-year-old patient has persistent skin rashes and itching unresponsive to conventional treatments. After extensive testing, including a skin biopsy and bone marrow examination, a diagnosis of indolent systemic mastocytosis with associated skin lesions is made.
Complete blood count (CBC) with differential, bone marrow biopsy results, tryptase levels, genetic testing (KIT mutation analysis), documentation of symptoms (skin manifestations, gastrointestinal issues, bone pain, fatigue), other relevant laboratory findings, imaging studies (if performed).
- Payment Status: Active
- Specialties:Hematology, Oncology, Allergy/Immunology, Dermatology
- Place of Service:Office, Inpatient Hospital, Outpatient Hospital, Independent Clinic