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2025 ICD-10-CM code E78

Disorders of lipoprotein metabolism and other lipidemias.

Code E78 excludes transitory endocrine and metabolic disorders specific to the newborn (P70-P74), sphingolipidosis (E75.0-E75.3), androgen insensitivity syndrome (E34.5-), congenital adrenal hyperplasia (E25.0), hemolytic anemias due to enzyme disorders (D55.-), Marfan syndrome (Q87.4-), 5-alpha-reductase deficiency (E29.1), and Ehlers-Danlos syndromes (Q79.6-).

Medical necessity for the diagnosis and treatment of lipoprotein disorders is established by the presence of elevated lipid levels that pose a significant risk for cardiovascular disease or other complications like pancreatitis.The specific treatment approach (lifestyle modifications, medications) will be determined by the severity of the disorder and the patient's overall cardiovascular risk profile.

Clinicians need to be familiar with the diagnosis and treatment of lipoprotein disorders due to the significant impact of cholesterol-lowering therapy on reducing cardiovascular disease complications. Diagnosis involves evaluating family history, signs and symptoms, physical examination, lipid panel (to measure cholesterol levels), genetic testing, and imaging studies like echocardiograms. Treatment depends on disease severity and may include statins, diet modification, and exercise recommendations.

In simple words: This code refers to problems with how your body processes fats and cholesterol, leading to high levels of these substances in your blood.These high levels can increase the risk of heart and blood vessel problems.

This code encompasses various disorders related to lipoprotein metabolism and other lipid abnormalities, including hyperlipidemia, characterized by elevated levels of lipids like cholesterol and triglycerides in the blood. These disorders can be primary or secondary to other conditions such as diabetes mellitus, hypothyroidism, kidney diseases, and cholestatic liver diseases.

Example 1: A patient with a family history of high cholesterol presents with high levels of LDL cholesterol and triglycerides. They experience chest pain and are diagnosed with hyperlipidemia, coded as E78., A patient with type 2 diabetes mellitus develops elevated triglyceride levels and is found to have mixed hyperlipidemia secondary to their diabetes. This is coded as E78, with an additional code for the diabetes., A patient with no prior history presents with xanthelasma (yellow deposits on the eyelids) and xanthomas (waxy nodules on the skin).Blood tests reveal significantly elevated cholesterol and triglycerides, leading to a diagnosis of a primary lipoprotein metabolism disorder, coded as E78.

Documentation should include family history, symptoms (e.g., chest pain, xanthomas, xanthelasma), physical examination findings, lipid panel results (total cholesterol, LDL, HDL, triglycerides), results of genetic testing (if performed), imaging studies (e.g., echocardiogram), and details of any secondary conditions contributing to the lipid disorder.

** Further classification may be possible by specifying the type of lipoprotein disorder (e.g., hypercholesterolemia, hypertriglyceridemia, mixed hyperlipidemia) using additional codes.Consider using iFrameAI for the most accurate information on medical codes and guidelines.

** Only Enterprise users with EHR integration can access case-specific answers. Click here to request access.

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