2025 ICD-10-CM code E84.8
(Active) Effective Date: N/A Metabolic disorders - Cystic Fibrosis 4 Endocrine, Nutritional and Metabolic Diseases Feed
Cystic fibrosis with other manifestations. This code is used for cases of cystic fibrosis where the manifestations are not primarily respiratory or intestinal.
The medical necessity for the use of E84.8 is established by the confirmed diagnosis of cystic fibrosis and the presence of manifestations affecting systems other than primarily the respiratory or intestinal systems. The documentation should clearly demonstrate the link between cystic fibrosis and these additional manifestations.
Diagnosis of cystic fibrosis involves reviewing patient history, symptoms, and conducting a physical exam. Lab tests may include blood tests for immunoreactive trypsinogen, stool tests for chymotrypsin, sputum culture, and a chloride sweat test. Newborn screening and genetic testing for the CFTR gene mutation are also used. Treatment options include medications like ivacaftor, lumacaftor, or tezacaftor, often in combination. Additional treatments depend on the specific manifestations and complications.
In simple words: This code is used when someone has cystic fibrosis, a genetic disease that causes thick mucus buildup in the body.It's used when the problems caused by cystic fibrosis aren't mainly in the lungs or intestines, but in other parts of the body.
Cystic fibrosis with other manifestations.Includes: mucoviscidosis. Code also: exocrine pancreatic insufficiency (K86.81)
Example 1: A patient with cystic fibrosis experiences male infertility due to blockage of the vas deferens by mucus.This manifestation is not primarily respiratory or intestinal, therefore E84.8 is the appropriate code., A female patient with cystic fibrosis is found to have reduced fertility, a manifestation outside of the respiratory and intestinal systems. The correct code to use is E84.8., A patient with known cystic fibrosis develops kidney stones. As kidney stones are not a primary respiratory or intestinal manifestation of CF, E84.8 would be used.
Documentation should support the diagnosis of cystic fibrosis and specify the "other" manifestations present, clearly indicating that they are not primarily respiratory or intestinal. This could include documentation of symptoms, physical exam findings, lab results (sweat chloride test, genetic testing), and imaging studies.If infertility is the manifestation, documentation of blocked vas deferens or other reproductive complications related to CF should be included.
- Specialties:Pulmonology, Gastroenterology, Endocrinology, Genetics, Reproductive Endocrinology, Urology, Nephrology
- Place of Service:Inpatient Hospital, Outpatient Hospital, Physician's Office, Independent Clinic, Federally Qualified Health Center, etc.