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2025 ICD-10-CM code L27.0

Generalized skin eruption due to drugs and medicaments taken internally. Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).

Code L27.0 is used for generalized skin eruptions due to drugs and medicaments taken internally. It should be used in conjunction with an additional code to specify the drug causing the adverse reaction (T36-T50 with fifth or sixth character 5). Do not use this code for localized drug-induced skin reactions.

The medical necessity for using L27.0 is established when a generalized skin eruption is directly related to the internal administration of a drug or medicament. This causal relationship should be supported by clinical findings and documentation.

In simple words: A widespread skin rash caused by medications taken by mouth.

Generalized skin eruption due to drugs and medicaments taken internally. Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Example 1: A patient presents with a generalized rash after starting a new antibiotic. The rash is determined to be an adverse reaction to the medication. Code L27.0 is used to document the skin eruption., A patient develops hives and itching all over their body after taking pain medication. This widespread reaction is documented using L27.0, along with a code to specify the drug causing the reaction., An individual experiences a diffuse skin rash as a side effect of chemotherapy. The generalized skin eruption is coded as L27.0, with an additional code identifying the specific chemotherapy drug.

Diagnosis, clinical findings describing the characteristics of the rash (e.g., maculopapular, vesicular, pustular), location and extent of the eruption, and the medication suspected of causing the reaction. If drug allergy testing is performed, results should also be documented.

** Excludes1: allergy NOS (T78.40)Excludes2: adverse food reaction, except dermatitis (T78.0-T78.1), contact dermatitis (L23-L25), drug photoallergic response (L56.1), drug phototoxic response (L56.0), urticaria (L50.-)

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