2025 ICD-10-CM code L51.3
Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome. This condition involves skin and mucous membrane damage covering 10-30% of the body surface area.
Medical necessity is established by the severity of the skin and mucous membrane involvement, the presence of systemic symptoms, and potential complications.Treatment is aimed at preventing further skin damage, managing pain and discomfort, addressing potential infections and complications, and providing supportive care to promote healing.
Physicians involved in diagnosing and managing L51.3 include dermatologists, allergists, and critical care specialists.They are responsible for identifying the underlying cause, providing supportive care (such as fluids, pain management, and wound care), and potentially prescribing medications like corticosteroids or immunoglobulins.They must also educate patients and families about the disease and potential complications.In severe cases, consultation with ophthalmologists, gynecologists, or other specialists may be necessary.
In simple words: Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome is a serious skin reaction usually caused by a medication. It makes your skin and mucous membranes peel, blister, and become very painful.It can affect your mouth, eyes, genitals, and other parts of your body. It can also cause problems with your internal organs and make you very sick.
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) overlap syndrome is a severe cutaneous drug reaction affecting 10-30% of the body surface area (BSA). It's characterized by destruction and detachment of the skin epithelium and mucous membranes, presenting with widespread blistering, ulceration, and necrosis.Symptoms begin with fever, headache, cough, keratoconjunctivitis, and body aches, progressing to a flat, red or purple rash with blisters. Mucous membrane involvement affects the oropharynx, eyes, genitalia, and anus, leading to pain, hypersalivation, photophobia, and dysuria.Visceral involvement can include hematological, respiratory, and digestive complications.
Example 1: A 45-year-old female develops a painful rash with blisters after starting a new anticonvulsant medication.Mucous membrane involvement is noted in her mouth and eyes.Skin detachment affects 15% of her BSA, leading to a diagnosis of SJS/TEN overlap syndrome., A 25-year-old male presents with fever, body aches, and a spreading rash after taking antibiotics for a respiratory infection.He develops blisters and skin peeling affecting 20% of his BSA, consistent with SJS/TEN overlap syndrome.Mycoplasma pneumoniae infection is identified as a possible contributing factor., A 60-year-old male with a history of gout develops a severe skin reaction with extensive blistering and skin detachment covering 25% of his BSA after increasing his allopurinol dosage.He experiences pain, fever, and mucosal involvement, diagnosed as SJS/TEN overlap syndrome.
Documentation should include the percentage of BSA affected, detailed descriptions of skin and mucosal lesions, presence of systemic symptoms, causative medications or infections, and any relevant medical history.Photographs of the lesions can be helpful.Consultations and interventions by specialists should be documented. Diagnostic testing results and treatment plans should also be included.
- Specialties:Dermatology, Allergy and Immunology, Critical Care Medicine
- Place of Service:Inpatient Hospital