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2025 ICD-10-CM code N46.0

Azoospermia: Complete absence of spermatozoa in semen.

Appropriate coding requires accurate documentation of the cause of azoospermia when known.If the cause is unknown, code N46.0 is used.Additional codes may be required to specify the underlying condition.

Medical necessity for investigations into azoospermia is established by the patient's desire for biological children and a diagnosis of male infertility.Testing and procedures are necessary to determine the underlying cause and explore options such as assisted reproductive technologies (ART).

Urologist, reproductive endocrinologist, or infertility specialist.

IMPORTANT:N46.01 (Organic azoospermia), N46.02 (Azoospermia due to extratesticular causes),N46.021 (Azoospermia due to drug therapy), N46.022 (Azoospermia due to infection), N46.023 (Azoospermia due to obstruction of efferent ducts), N46.024 (Azoospermia due to radiation), N46.025 (Azoospermia due to systemic disease), N46.029 (Azoospermia due to other extratesticular causes).

In simple words: Azoospermia means there are no sperm in a man's semen, making it impossible for him to father a child naturally.

Azoospermia is characterized by the complete absence of spermatozoa in the semen, resulting in male infertility.This condition can be caused by various factors, including germinal cell aplasia (failure of sperm cell development), complete spermatogenic arrest (cessation of sperm production), or extratesticular issues such as obstructions, infections, or systemic diseases.Diagnosis involves semen analysis revealing zero sperm count.

Example 1: A 35-year-old male presents with primary infertility (never fathered a child) and undergoes semen analysis revealing azoospermia.Further investigation, including hormonal testing and testicular biopsy, is needed to determine the underlying cause (e.g., genetic defect, obstruction)., A 42-year-old male with a history of chemotherapy for cancer presents with secondary infertility (previously fathered a child). Semen analysis shows azoospermia, likely due to drug-induced damage to the testes.Counseling on fertility options is provided., A 28-year-old male with a history of mumps orchitis (testicular inflammation) as a child presents with azoospermia.Imaging studies might reveal obstructions in the reproductive tract, possibly requiring surgical intervention.

* Detailed patient history including age, duration of infertility, past medical history (including mumps, infections, trauma, surgeries), medications, family history of infertility.* Results of semen analysis (including sperm concentration, motility, morphology).* Hormonal levels (FSH, LH, testosterone).* Genetic testing (karyotyping, Y-chromosome microdeletion analysis) as indicated.* Imaging studies (ultrasound, MRI) if indicated to assess for structural abnormalities.* Testicular biopsy (if necessary for diagnosis and prognosis).

** Azoospermia is a serious condition that can have significant psychological impact on the patient and their partner.Counseling and support should be considered part of comprehensive care.

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