2025 ICD-10-CM code Q98.8
Other specified sex chromosome abnormalities, male phenotype.
Medical necessity for services related to Q98.8 hinges on establishing a causal link between the specific sex chromosome abnormality and the presenting signs, symptoms, or conditions.This requires comprehensive genetic evaluation and correlation with the individual's clinical presentation.The documentation should clearly justify the need for diagnostic testing, genetic counseling, or other interventions based on the specific abnormality identified.
Clinical responsibility for diagnosing and managing Q98.8 typically falls under geneticists, endocrinologists, and other specialists depending on the specific phenotypic presentation. This involves a thorough evaluation of the individual's karyotype, physical characteristics, and associated medical issues. Management may involve hormonal therapy, genetic counseling, and addressing specific health concerns arising from the chromosomal abnormality.
In simple words: This code indicates a rare genetic condition where a male has an unusual combination of sex chromosomes, different from the typical XY pattern.It covers various specific abnormalities not covered by other, more common conditions.
This code represents a specified sex chromosome abnormality in a male individual, excluding those already classified in Q98.0-Q98.7 and Q98.9.This includes various rare sex chromosome abnormalities beyond Klinefelter syndrome (47,XXY, 48,XXXY, etc.), 47,XYY syndrome, 46,XX males, and other structural or mosaic variations.
Example 1: A male infant presents with ambiguous genitalia.Genetic testing reveals a rare sex chromosome rearrangement, fitting the criteria for Q98.8., An adolescent male experiencing developmental delays and learning difficulties undergoes karyotyping, which identifies a complex sex chromosome mosaicism not otherwise classified, leading to the assignment of Q98.8., A male adult with infertility issues is found to have a rare sex chromosome abnormality through genetic analysis, classified under Q98.8 after other specific conditions are ruled out.
Thorough documentation for Q98.8 should include the complete karyotype analysis report, detailed phenotypic description of the patient, and any associated clinical findings.The specific genetic abnormality should be clearly stated. Any other relevant diagnostic tests, imaging studies, or specialist consultations should also be documented.
** This code is specifically for use in individuals with a male phenotype. It is crucial to distinguish Q98.8 from other related codes within the Q90-Q99 block and to ensure that it is not used when a more specific code applies.
- Specialties:Genetics, Endocrinology, Urology, Pediatrics
- Place of Service:Inpatient Hospital, On Campus-Outpatient Hospital, Off Campus-Outpatient Hospital, Office, Independent Clinic, Federally Qualified Health Center